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Drug release behavior of chitosan/gelatin network polymer microsphere

机译：壳聚糖/明胶网络聚合物微球的释药行为

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Recently, more attention has been attracted by intelligent drug delivery systems (DDS), because the release of drug can be controlled via the system feedback responding to pathologic environment signals, Using natural polymers such as chitosan to compose this kind of pulsed DDS will be of benefit, because chitosan [α(1→4)2-amino-2-deoxy-β-D-glucan] is one of the abundantly available polysaccharides in nature. As we know, chitosan is usually obtained by alkaline deacetylation of chitin, the principal component of shells of living organisms, e.g. crab and shrimp. Chitosan has low toxicity, is biocompatible and can reduce lipid level. Nishimura et al. have loaded adriamycin to chitosan beads and studied their antitumour activity Chandy et al. have used chitosan as a matrix for oral sustained delivery of ampicillin. The present authors have developed a pH-responsive semi-interpenetrating polymer network hydrogel of chitosan and polyether. The pulsed-release behavior of chlorhexidini acetas and cimetidine is studied. Considering the antiacid and antiulcer characteristics of chitosan, in this work, a hybrid polymer network (HPN) microspheres of chitosan and gelatin were synthesized via co-crosslinking them with glutaraldehyde, and an investigation was made on the pH-sensitive pulsed-release behavior of cimetidine-loaded microspheres for weakening the side reaction of the drug for the treatment of duodenal and benign gastric ulceration.
机译：近年来，智能药物递送系统（DDS）引起了更多关注，因为可以通过响应病理环境信号的系统反馈来控制药物的释放。使用天然聚合物（例如壳聚糖）来组成这种脉冲DDS壳聚糖[α（1→4）2-氨基-2-脱氧-β-D-葡聚糖]是自然界中大量可用的多糖之一，因此具有很大的优势。众所周知，壳聚糖通常是通过几丁质的碱性脱乙酰作用而获得的，几丁质是生物体的壳的主要成分，例如壳聚糖。螃蟹和虾。壳聚糖毒性低，具有生物相容性，可以降低脂质水平。 Nishimura等。已将阿霉素加载到壳聚糖珠上并研究了其抗肿瘤活性Chandy等。已使用壳聚糖作为口服持续递送氨苄西林的基质。本发明人已经开发了壳聚糖和聚醚的pH响应性半互穿聚合物网络水凝胶。研究了扑热息痛和西咪替丁的脉冲释放行为。考虑到壳聚糖的抗酸和抗溃疡特性，在这项工作中，壳聚糖和明胶的杂化聚合物网络（HPN）微球是通过将它们与戊二醛共交联而合成的，并研究了pH敏感的脉冲释放行为。装有西咪替丁的微球，可减弱药物治疗十二指肠和良性胃溃疡的副反应。

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