Trans-acting factor binding to negative control region (NCR2) in 5' flanking sequence of human β-globin gene

CHEN Shiyou; JIANG Chu; QIAN Ruolan

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Trans-acting factor binding to negative control region (NCR2) in 5' flanking sequence of human β-globin gene

机译：反式作用因子与人β-珠蛋白基因5'侧翼序列中的负控制区（NCR2）结合

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Human β-globin gene family provides an ideal model for studying the expression and regulation of eukaryotic gene. The five transcriptional active genes arranged 5' ε-~Gγ-~Aγ-δ-β 3' in the order that they are expressed during development. However, the molecular regulatory mechanism of the human globin gene expression remains to be defined. β-globin gene normally expressed in the adult bone marrow, but not in the embryonic stage, which suggests that there may be a silencing mechanism for the expression of human β-globin gene during the embryonic and fetal stage.

机译：人β-珠蛋白基因家族为研究真核基因的表达和调控提供了理想的模型。五个转录活性基因按照在发育中表达的顺序排列了5'ε-〜Gγ-〜Aγ-δ-β3'。然而，人类球蛋白基因表达的分子调控机制仍有待确定。 β-珠蛋白基因通常在成年骨髓中表达，但在胚胎期不表达，这表明人β-珠蛋白基因在胚胎和胎儿期表达可能存在沉默机制。

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来源
《Chinese science bulletin》 |1996年第17期|p.1462-1465|共4页
作者
CHEN Shiyou; JIANG Chu; QIAN Ruolan;
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作者单位

Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;

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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
human β-globin gene; negative control element; trans-acting factor;

机译：人β-珠蛋白基因;负调控元件;反式作用因子;

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专利

1. Trans-acting factor binding to negative control region (NCR2) in 5' flanking sequence of human β-globin gene [J] . CHEN Shiyou, JIANG Chu, QIAN Ruolan Chinese science bulletin . 1996,第17期

机译：反式作用因子与人β-珠蛋白基因5'侧翼序列中的负控制区（NCR2）结合
2. A DNA-binding protein factor in K562 nuclear extract interacts with positive control region （PCR） in the 5＇-flanking sequence of human β-globin gene [J] . HUYULONG, YADICHEN, TONGSUN, 细胞研究：英文版 . 1993,第001期

机译：K562核提取物中的DNA结合蛋白因子与人β-珠蛋白基因5'侧翼序列中的阳性控制区（PCR）相互作用
3. SEQUENCES WITHIN AND FLANKING HYPERSENSITIVE SITES 3 AND 2 OF THE BETA-GLOBIN LOCUS CONTROL REGION REQUIRED FOR SYNERGISTIC VERSUS ADDITIVE INTERACTION WITH THE EPSILON-GLOBIN GENE PROMOTER [J] . Jackson JD, Miller W, Hardison RC Nucleic Acids Research . 1996,第21期

机译：β-球蛋白位置控制区域的超敏感性位点3和2的内部和侧面序列，需要与ε-球蛋白基因启动子进行协同与加性相互作用
4. Predicting sequence and structural specificities of RNA binding regions recognized by splicing factor SRSF1 [C] . Xin Wang, Liran Juan, Junjie Lv, International Conference on Bioinformatics Computational Biology . 2011

机译：通过剪接因子SRSF1认识到RNA结合区域的序列和结构特异性
5. Identification of Structural Signatures Within Transcription Factor Binding Sites and Their Flanking Regions in Saccharomyces cerevisiae Enhanced Through DeltaTRX Based Multiple Sequence Alignment. [D] . Schulze, Katharina. 2014

机译：通过基于DeltaTRX的多序列比对增强酿酒酵母中转录因子结合位点及其侧翼区域内的结构特征。
6. Sequences within and flanking hypersensitive sites 3 and 2 of the beta-globin locus control region required for synergistic versus additive interaction with the epsilon-globin gene promoter. [O] . J D Jackson, W Miller, R C Hardison 1996

机译：β-球蛋白基因座控制区的超敏位点3和2内和侧翼的序列需要与ε-球蛋白基因启动子协同进行加性相互作用。
7. Nucleotide Sequence and Transcriptional Analysis of the Flanking Region of the Gene (spb) for the trans-Acting Factor That Controls Light-Mediated Expression of the puf Operon in Rhodobacter sphaeroides [O] . H. Mizoguchi, T. Masuda, K. Nishimura, 1997

机译：用于控制脱牙菌乳糖型脓肿术术的旋转作用因子的基因（SPB）的侧翼区域的核苷酸序列和转录分析

Trans-acting factor binding to negative control region (NCR2) in 5' flanking sequence of human β-globin gene

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