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HSP90β participates in regulation of heat shock gene expression

机译：HSP90β参与热休克基因表达的调控

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摘要

Heat shock proteins (HSP) are a group of proteins highly conserved in evolution. They play important physiological roles, usually as molecular chaperones in living cells, and take great parts in cell protection process against stress, and in signal transduction as well, HSP70 and HSP90 are the major HSPs expressed in human peripheral lymphocytes upon heat shock. HSP90 consists of two copies, designated as HSP90α and HSP90β. Heat shock factors (HSF), the trans regulators, participate in the regulation of HSP gene transcription. Different from HSP70 which is dramatically induced by stress, both heat shock and cold shock, HSP90 expresses at a relatively high level physiologically and may exist as complexes with various steroid receptors or some important components in signal transduction pathway, and plays a role of specific molecular chaperone. The aim of this note is to study if HSP90 does participate in an auto-regulation and in the regulation of other heat shock genes, and if so, which one of the two HSP90s plays the dominant role in human cells.
机译：热激蛋白（HSP）是一组在进化中高度保守的蛋白。它们起着重要的生理作用，通常作为活细胞中的分子伴侣，并在细胞对抗压力的保护过程中起着重要作用，在信号转导中，HSP70和HSP90也是热激后在人外周血淋巴细胞中表达的主要HSP。 HSP90由两个副本组成，分别称为HSP90α和HSP90β。热休克因子（HSF）是反式调节因子，参与HSP基因转录的调节。与受热激和冷激两种应激强烈诱导的HSP70不同，HSP90在生理上以较高水平表达，并可能与各种类固醇受体或信号转导途径中的一些重要成分以复合物形式存在，并起特定分子的作用。伴侣。本说明的目的是研究HSP90是否确实参与了自动调节和其他热休克基因的调节，如果是，那么两个HSP90中的哪一个在人细胞中起主导作用。

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