Theoretical strategies for high-resolution mapping of complex genetic disorders in humans

Luo Zewei; Zhang Rongmei

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Theoretical strategies for high-resolution mapping of complex genetic disorders in humans

机译：高分辨率解析人类复杂遗传疾病的理论策略

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Positional cloning of gene(s)underlying a complex disease trail poses requirement of a high- resolution linkage map between the disease locus and genetic marker loci. Recent researches have shown that this may be achieved through appropriately modeling and screening linkage disequilibrium between the canditate marker locus and the major trait locus. However, these models were restricted to the circumstances where genotyping at the disease locus was feasible.

机译：复杂疾病线索下基因的位置克隆提出了在疾病基因座和遗传标记基因座之间建立高分辨率连锁图的要求。最近的研究表明，这可以通过适当地建模和筛选候选标记位点和主要性状位点之间的连锁不平衡来实现。但是，这些模型仅限于在疾病位点进行基因分型的情况。

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《Chinese science bulletin》 |1999年第3期|p.193-198|共6页
作者
Luo Zewei; Zhang Rongmei;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
positional cloning; high-resolution genetic mapping; complex genetic traits;

机译：位置克隆高分辨率遗传作图;复杂的遗传特征;

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专利

1. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: Organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex [J] . Thierry Lagrange, Tae-Kyung Kim, George Orphanides Proceedings of the National Academy of Sciences of the United States of America . 1996,第20期

机译：通过位点特异性蛋白质-DNA光交联进行核蛋白复合物的高分辨率定位：人TBP-TFIIA-TFIIB-DNA季复合物的组织
2. Brain imaging genetics in ADHD and beyond – Mapping pathways from gene to disorder at different levels of complexity [J] . Marieke Klein, Marten Onnink, Marjolein van Donkelaar, Neuroscience and Biobehavioral Reviews . 2017,第期

机译：脑成像在ADHD及其外映射途径在不同水平的复杂性紊乱中
3. Discovering the Genetics of Complex Disorders Through Integration of Genomic Mapping and Transcriptional Profiling [J] . Robert S. Danziger Ming You Huda Akil Current Hypertension Reviews . 2005,第1期

机译：通过整合基因组图谱和转录谱分析发现复杂疾病的遗传学
4. Using Projection and 2D Plots to Visually Reveal Genetic Mechanisms of Complex Human Disorders [C] . Boonthanome Nouanesengsy, Sang-Cheol Seok, Han-Wei Shen, IEEE Symposium on Visual Analytics Science and Technology . 2009

机译：使用预测和2D曲线在视觉上揭示复杂人类疾病的遗传机制
5. Development of mapping by admixture linkage disequilibrium for understanding human complex genetic diseases. [D] . Schramm, Heather Elizabeth. 2003

机译：通过混合连锁不平衡作图的发展，以了解人类复杂的遗传疾病。
6. A strategy for constructing high-resolution genetic maps of the human genome: a genetic map of chromosome 17p ordered with meiotic breakpoint-mapping panels. [O] . S C Gerken, H Albertsen, T Elsner, 1995

机译：构造人类基因组高分辨率遗传图谱的策略：染色体17p的遗传图谱与减数分裂断点映射面板一起排列。
7. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex. [O] . Lagrange, T, Kim, T K, Orphanides, G, 1996

机译：通过位点特异性蛋白质-DNA光交联进行核蛋白复合物的高分辨率作图：人TBP-TFIIA-TFIIB-DNA季复合物的组织。

Theoretical strategies for high-resolution mapping of complex genetic disorders in humans

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