DNA-based immunization against hepatitis B surface antigen carrying preS epitopes

Hui Jingyi; Li Guangdi; Kong Yuying

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DNA-based immunization against hepatitis B surface antigen carrying preS epitopes

机译：针对携带preS表位的乙肝表面抗原的基于DNA的免疫

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Three plasmid expression vectors containing modified hepatitis B surface antigen (HBsAg)carrying preS epitopes were constructed. Transient expression after in vitro transfec- tion in COS-M6 cells showed that under the transcriptional control of human cytomegalovirus (CMV)immediate early promoter, fusion genes expressed the modified HBV envelope proteins which were efficiently secreted into culture medium and presented HBsAg, preS1 and preS2 antigenicity.

机译：构建了三个带有修饰的携带preS表位的乙肝表面抗原（HBsAg）的质粒表达载体。在COS-M6细胞中进行体外转化后的瞬时表达表明，在人类巨细胞病毒（CMV）介导的早期启动子的转录控制下，融合基因表达了修饰的HBV包膜蛋白，这些蛋白有效地分泌到培养基中并呈递HBsAg，preS1和preS2抗原性。

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来源
《Chinese science bulletin》 |1999年第7期|p.620-623|共4页
作者
Hui Jingyi; Li Guangdi; Kong Yuying;
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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
preS epitopes; hepatitis B surface antigen(HBsAg); DNA-based immunization;

机译：preS表位;乙型肝炎表面抗原（HBsAg）;基于DNA的免疫;

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专利

1. Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization. [J] . Mancini M, Hadchouel M, Tiollais P, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第10期

机译：基于DNA的免疫后，IFN-γ分泌的T细胞在乙型肝炎表面抗原转基因小鼠模型中调节乙型肝炎病毒mRNA表达。
2. Regulation of Hepatitis B Virus mRNA Expression in a Hepatitis B Surface Antigen Transgenic Mouse Model by IFN-γ-Secreting T Cells After DNA-Based Immunization [J] . Maryline Mancini, Michelle Hadchouel, Pierre Tiollais, The journal of immunology . 1998,第10期

机译：DNA免疫后通过IFN-γ分泌T细胞调节乙型肝炎表面抗原转基因小鼠模型中乙型肝炎病毒mRNA的表达
3. Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens. [J] . Lu M, Klaes R, Menne S, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2003,第3期

机译：通过用WHV表面抗原免疫接种诱导慢性携带者土拨鼠中土拨鼠肝炎病毒（WHV）表面抗原PreS区的抗体。
4. Novel Bacterial Delivery System with Attenuated Salmonella typhimurium Carrying Plasmid Encoding Mtb Antigen 85A for Mucosal Immunization Establishment of Proof of Principle in TB Mouse Model [C] . SHREEMANTA K. PARIDA, KRIS HUYGEN, BERNHARD RYFFEL, International Conference on Natural Products and Molecular Medicine . 2005

机译：新型细菌输送系统，具有减毒沙门氏菌培养质粒编码MTB抗原85A，用于粘膜免疫，在TB小鼠模型中的原理证明
5. Incidence, Durability, and Clinical Outcomes of Hepatitis B Surface Antigen Seroclearance in Patients with Chronic Hepatitis B [D] . Yip, Cheuk Fung. 2019

机译：慢性乙型肝炎患者乙型肝炎表面抗原血管疮的发病率，耐久性和临床结果
6. Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency [O] . Anna Czarnota, Anna Offersgaard, Anne Finne Pihl, 2020

机译：由携带丙型肝炎病毒包膜糖蛋白2表位的乙型肝炎病毒样颗粒免疫接种诱导的特异性抗体显示出不同的中和效率
7. Characterization of Complex B Cell Epitopes on Woodchuck Hepatitis Virus Surface Antigens by Using Plasmids Encoding Chimeric Proteins and DNA Immunization [O] . Zheng Xin, Schirmbeck Reinhold, Hilken Gero, 2002

机译：土拨鼠肝炎病毒表面抗原的复杂B细胞表位的表征通过使用编码嵌合蛋白和DNA免疫的质粒。

DNA-based immunization against hepatitis B surface antigen carrying preS epitopes

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