Effect of PKCαantisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

Sang Jianli; Wang Yongchao

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Effect of PKCαantisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

机译：PKCα反义RNA对人乳腺癌细胞增殖及cyclinD1和CDK4表达的影响

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The role of PKCαin human breast cancer cell proliferation and expression of cyclinD1 and CDK4 has been investigated using inhibition of PKCαexpression by its antisense RNA. When PKCαexpression was inhibited the rate of cell proliferation decreased apparently and the Levels of vyclinD1 and CDK mRNA were lower than the control. The results showed that PKCα, a key member of signal transduction system, played an important role in human breast Cancer cell proliferation and had a close relationship with expression of cyclinD1 and CDK4 Which control start of cell cycle.

机译：已经通过使用PKCα的反义RNA抑制PKCα的表达来研究PKCα在人乳腺癌细胞增殖以及cyclinD1和CDK4表达中的作用。当PKCα表达被抑制时，细胞增殖速率明显降低，vyclinD1和CDK mRNA水平低于对照组。结果表明，信号转导系统的关键成员PKCα在人乳腺癌细胞增殖中起着重要作用，并且与控制细胞周期开始的cyclinD1和CDK4的表达密切相关。

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《Chinese science bulletin》 |1999年第12期|p.1110-1114|共5页
作者
Sang Jianli; Wang Yongchao;
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原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
breast cancer; PKCα; cell proliferation;

机译：乳腺癌;PKCα;细胞增殖;

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专利

1. Effects of CDK4 antisense RNA on Human breast cancer cell proliferation and expression of cyclinD1, cycline and CDK2 [J] . Sang Jianli, Wang Yongchao Chinese science bulletin . 1999,第6期

机译：CDK4反义RNA对人乳腺癌细胞增殖及cyclinD1，cycline和CDK2表达的影响
2. ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro [J] . Qingming Jiang, Hui Zhang, Ping Zhang Journal of experimental & clinical cancer research : . 2011,第1期

机译：ShRNA介导的MTA1基因沉默影响体外乳腺癌细胞系MDA-MB-231和MCF-7的ER alpha，MMP-9，CyclinD1的蛋白表达以及侵袭性，增殖
3. Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression. [J] . Grillo M, Bott MJ, Khandke N, Breast cancer research and treatment. . 2006,第2期

机译：验证细胞周期蛋白D1 / CDK4作为MCF-7乳腺癌细胞中的抗癌药物靶标：调节细胞周期蛋白D1的过表达和siRNA介导的内源性细胞周期蛋白D1和CDK4表达的抑制作用。
4. Down-Regulation of Survivin Expression by siRNA Suppresses Proliferation and Enhances Chemosensitivity in Human Pancreatic Cancer Cell Line Panc-1 [C] . Kaiwen Guo, Wenjian Song, Yeli Gong, International Conference on Measuring Technology and Mechatronics Automation . 2015

机译：siRNA下调Survivin表达抑制人胰腺癌细胞系Panc-1的增殖并增强其化学敏感性。
5. The Role of aPKCs and aPKC Inhibitors in Cell Proliferation and Invasion in Breast and Ovarian Cancer [D] . Smalley, Tracess B. 2020

机译：APKCS和APKC抑制剂在乳腺癌和卵巢癌中的细胞增殖和侵袭中的作用
6. ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha MMP-9 CyclinD1 and invasiveness proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro [O] . Qingming Jiang, Hui Zhang, Ping Zhang 2011

机译：ShRNA介导的MTA1基因沉默影响体外乳腺癌细胞系MDA-MB-231和MCF-7的ER alphaMMP-9CyclinD1的蛋白表达以及侵袭性增殖
7. Long non‑coding RNA heart and neural crest derivatives expressed�2‑antisense RNA�1 overexpression inhibits the proliferation of cancer cells by reducing RUNX2 expression in triple‑negative breast cancer [O] . Min Wei, Lei Liu, Zhiwei Wang 2019

机译：长期非编码RNA心脏和神经嵴衍生物表达�2-反义RNA�1过表达抑制了在三阴性乳腺癌中的RUNX2表达中抑制了癌细胞的增殖
8. Inhibition of Estrogen Receptor Coactivator Expression by Antisense Oligodeoxynucleotides and Effect on Breast Cancer Cell Proliferation and Gene Expression [R] . Smith, C. L. 2003

机译：反义寡核苷酸对雌激素受体辅激活因子表达的抑制作用及对乳腺癌细胞增殖和基因表达的影响

Effect of PKCαantisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

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