Crystallization and preliminary crystallographic analysis of [A21Ser-B27Arg-B30Thr-NH_2] -human insulin

JIN Lei; ZHANG Lin; WANG Dacheng; Jan Markussen

首页> 外文期刊>Chinese science bulletin >Crystallization and preliminary crystallographic analysis of [A21Ser-B27Arg-B30Thr-NH_2] -human insulin

【24h】

Crystallization and preliminary crystallographic analysis of [A21Ser-B27Arg-B30Thr-NH_2] -human insulin

机译：[A21Ser-B27Arg-B30Thr-NH_2]-人胰岛素的结晶及初步晶体学分析

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Some experiments have shown that the properties of single mutation can be synthesized in a mutant with multiple mutations. Following this idea, SRN-HI was prepared. Markussen et al. reported that a high stability and a prolonged action could be created from mutations AsnA21Ser and ThrB27Arg respectively. Therefore, a double property was expected to appear in SRN-HI, which has been proved to be true by biological test. Obviously, it is worth while to study the structural basis of these synthetic properties through X-ray structural analysis.

机译：一些实验表明，单个突变的特性可以在具有多个突变的突变体中合成。遵循这个想法，SRN-HI得以准备。 Markussen等。报告指出，分别由突变AsnA21Ser和ThrB27Arg可以产生高稳定性和长效作用。因此，预期在SRN-HI中会出现双重性质，这已经通过生物学测试证明是正确的。显然，值得通过X射线结构分析研究这些合成特性的结构基础。

著录项

来源
《Chinese science bulletin》 |1995年第11期|p.949-952|共4页
作者
JIN Lei; ZHANG Lin; WANG Dacheng; Jan Markussen;
展开▼
作者单位

Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类自然科学现状及发展;
关键词
insulin; multiple mutations; high stability; prolonged action; crystallographic data;

机译：胰岛素;多重突变;高稳定性;延长作用;晶体学数据;

相似文献

外文文献
中文文献
专利

1. Crystallization and preliminary crystallographic analysis of [A21Ser-B27Arg-B30Thr-NH_2] -human insulin [J] . JIN Lei, ZHANG Lin, WANG Dacheng, Chinese science bulletin . 1995,第11期

机译：[A21Ser-B27Arg-B30Thr-NH_2]-人胰岛素的结晶及初步晶体学分析
2. Crystallization and preliminary crystallographic analyses of human insulin mutant B9(Ser→Asp) in different aggregation forms [J] . Liu Xinqi, Jin Lei, Zhang Ying Chinese science bulletin . 1999,第9期

机译：不同聚集形式的人胰岛素突变体B9（Ser→Asp）的结晶和初步晶体学分析
3. Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex [J] . Altenfeld Anika, Wohlgemuth Sabine, Wehenkel Annemarie, Acta crystallographica. Section F, Structural biology communications . 2015,第4期

机译：人Rod-Zwilch-ZW10（RZZ）配合物的配合物组装，结晶和初步X射线晶体学分析
4. CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC ANALYSIS OF MONODEHYDROASCORBATE RADICAL REDUCTASE FROM CUCUMBER [C] . Satoshi Sano, You-Na Kang, Hiroko Shigemizu, International Congress of Photosynthesis . 2005

机译：黄瓜单羟基血基岩固体还原酶的结晶及初步晶体分析
5. Expression, purification, crystallization and preliminary X-ray analysis of PR-AMP cyclohydrolase, a zinc binding enzyme from Methanobacterium thermoautotrophicum. [D] . Boju, Lorena. 2004

机译：PR-AMP环水解酶的表达，纯化，结晶和初步X射线分析，PR-AMP环水解酶是一种来自嗜热自养甲烷杆菌的锌结合酶。
6. Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein–DNA complex crystallization [O] . Shigeru Sakurai, Ken Kitano, Hiroshi Morioka, 2008

机译：人皮瓣核酸内切酶1催化结构域与带切口的DNA产物的结晶和初步结晶学分析：使用DPCS试剂盒可有效地使蛋白质-DNA复合物结晶
7. Crystallization and preliminary crystallographic analysis of the catalytic domain of human flap endonuclease 1 in complex with a nicked DNA product: use of a DPCS kit for efficient protein–DNA complex crystallization [O] . Sakurai, Shigeru, Kitano, Ken, Morioka, Hiroshi, 2007

机译：人皮瓣核酸内切酶1催化结构域与带切口的DNA产物的结晶和初步结晶学分析：使用DPCS试剂盒可有效地使蛋白质-DNA复合物结晶

Crystallization and preliminary crystallographic analysis of [A21Ser-B27Arg-B30Thr-NH_2] -human insulin

摘要

著录项

相似文献

相关主题

期刊订阅