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首页> 外文期刊>Chinese science bulletin >Association of lamin A/C with chromosomes in the mitosis of mouse thymus T lymphocytes
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Association of lamin A/C with chromosomes in the mitosis of mouse thymus T lymphocytes

机译：层粘连蛋白A / C与小鼠胸腺T淋巴细胞有丝分裂中的染色体的关系

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摘要

The nuclear lamina is a meshwork of intermediate filament-like fibrils situated immediately subjacent to the inner membrane of the nuclear envelope, Together with other proteinaceous elements such as the nuclear pore complex, the lamina forms part ofthe karyoskeleton, or structural framework of the nucleus. The lamina is thought to play a role in anchoring the nuclear envelope, and/or providing attachment sites for interphase chromatin. Mammalian somatic cells commonly contain three major lamins: A,B and C. During the interphase, these three polypeptides form a supramolecular assembly which is relatively resistant to solubilization by harsh chemical conditions. As to the components of lymphocyte, the results are controversial, While Rober et al. reported that there exists no lamin A/C in lymphocytes, Guilly et al, reported that there is no lamin A/C in the early stages of differentiation of T and B lymphocytes, but there exists lamin A/C in peripheral blood lymphocytes.
机译：核层是中间细丝状原纤维的网状结构，紧邻纤维膜的内膜，与其他蛋白质元素（如核孔复合体）一起形成核骨架或核结构框架的一部分。认为层板在锚定核包膜和/或提供相间染色质的附着位点中起作用。哺乳动物的体细胞通常包含三个主要的纤层蛋白：A，B和C。在相间过程中，这三个多肽形成超分子组装体，在恶劣的化学条件下相对抗溶解。至于淋巴细胞的组成，结果是有争议的，而Rober等。据报道，淋巴细胞中没有lamin A / C，Guilly等人报道在T和B淋巴细胞分化的早期阶段没有lamin A / C，但是外周血淋巴细胞中存在lamin A / C。

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