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首页> 外文期刊>Chromatographia >Development and Validation of an HPLC Method for the Determination of Dexamethasone, Dexamethasone Sodium Phosphate and Chloramphenicol in Presence of Each Other in Pharmaceutical Preparations
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Development and Validation of an HPLC Method for the Determination of Dexamethasone, Dexamethasone Sodium Phosphate and Chloramphenicol in Presence of Each Other in Pharmaceutical Preparations

机译：药物制剂中相互存在测定地塞米松，地塞米松磷酸钠和氯霉素的HPLC方法的建立和验证

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摘要

An HPLC method for the determination of dexamethasone, dexamethasone sodium phosphate and chloramphenicol in presence of each other in pharmaceutical preparations has been developed using a Shim-Pack CLC-ODS column (6.0 × 150 mm2). These analytes were separated under isocratic conditions. Various chromatographic parameters including linearity, precision and accuracy have been evaluated. The method was found to be suitable for analysis of these drug substances in presence of each other. The run time was less than 15 min. This method is suitable for application to various dosage forms.
机译：建立了使用Shim-Pack CLC-ODS色谱柱（6.0×150 mm2 ）在药物制剂中彼此存在时测定地塞米松，地塞米松磷酸钠和氯霉素的HPLC方法。这些分析物在等度条件下分离。已评估了各种色谱参数，包括线性，精度和准确性。发现该方法适用于彼此存在时对这些原料药的分析。运行时间少于15分钟。该方法适用于各种剂型。

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