Predicting electrophoretic mobility of beta-blockers in a water-methanol based electrolyte system

A. Jouyban; M. Khoubnasabjafari; H. K. Chan; K. D. Altria; B. J. Clark

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Predicting electrophoretic mobility of beta-blockers in a water-methanol based electrolyte system

机译：预测基于水-甲醇的电解质系统中β受体阻滞剂的电泳迁移率

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Applicability of a mathematical model to predict the electrophoretic mobility of structurally related analyses is shown using generated mobility data for beta-blockers in a mixed aqueousmethanolic buffer. The mobilities of atenolol, alprenolol, labetalol and metoprolol in binary mixed solvent buffers containing different concentrations of methanol have been employed to train the model. Then the mobilities of propranolol, timolol and acebutalol have been predicted using the trained model. The produced mean prediction errors employing two and one experimental data points for three beta-blockers are 1.6 and 2.8%, respectively, which is easily within experimental uncertainty.

机译：使用生成的β-阻滞剂在混合甲醇水溶液中的迁移率数据，显示了数学模型对结构相关分析的电泳迁移率进行预测的适用性。在含有不同浓度甲醇的二元混合溶剂缓冲液中，阿替洛尔，阿普洛尔，拉贝洛尔和美托洛尔的迁移率已被用于训练模型。然后，使用训练后的模型预测了普萘洛尔，噻吗洛尔和醋丁洛尔的迁移率。使用三种β受体阻滞剂的两个和一个实验数据点产生的平均预测误差分别为1.6和2.8％，这很容易在实验不确定性范围内。

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来源
《Chromatographia》 |2003年第4期|191-195|共5页
作者
A. Jouyban; M. Khoubnasabjafari; H. K. Chan; K. D. Altria; B. J. Clark;
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作者单位

School of Pharmacy Tabriz University of Medical Sciences;

Drug Applied Research Centre Tabriz University of Medical Sciences;

Faculty of Pharmacy The University of Sydney;

Pharmaceutical Development Glaxo Wellcome R D;

School of Pharmacy University of Bradford;

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正文语种 eng
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关键词
Capillary zone electrophoresis; Electrophoretic mobility; Beta-blockers; Water-methanol mixture; Mathematical modeling;

机译：毛细管区带电泳;电泳迁移率;β-阻滞剂;水-甲醇混合物;数学模型;

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1. Predicting electrophoretic mobility of beta-blockers in a water-methanol based electrolyte system [J] . Jouyban A., Khoubnasabjafari M., Chan HK., Chromatographia . 2003,第3a4期

机译：预测基于水-甲醇的电解质系统中β受体阻滞剂的电泳迁移率
2. Application of the Phenomenological Model to Electrophoretic Mobility in Mixed Solvent Electrolyte Systems in Capillary Zone Electrophoresis [J] . Chan HK, Jouyban A, Khoubnasabjafari M Iranian Journal of Pharmaceutical Research . 2010,第1期

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Predicting electrophoretic mobility of beta-blockers in a water-methanol based electrolyte system

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