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首页> 外文期刊>Chromosoma >Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila
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Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila

机译：hsp70基因簇在果蝇virilis组的两个密切相关物种中的进化和安排。

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摘要

To investigate the genetic basis of differing thermotolerance in the closely related species Drosophila virilis and Drosophila lummei, which replace one another along a latitudinal cline, we characterized the hsp70 gene cluster in multiple strains of both species. In both species, all hsp70 copies cluster in a single chromosomal locus, 29C1, and each cluster includes two hsp70 genes arranged as an inverted pair, the ancestral condition. The total number of hsp70 copies is maximally seven in the more thermotolerant D. virilis and five in the less tolerant D. lummei, with some strains of each species exhibiting lower copy numbers. Thus, maximum hsp70 copy number corresponds to hsp70 mRNA and Hsp70 protein levels reported previously and the size of heat-induced puffs at 29C1. The nucleotide sequence and spacing of the hsp70 copies are consistent with tandem duplication of the hsp70 genes in a common ancestor of D. virilis and D. lummei followed by loss of hsp70 genes in D. lummei. These and other data for hsp70 in Drosophila suggest that evolutionary adaptation has repeatedly modified hsp70 copy number by several different genetic mechanisms.
机译：要调查密切相关的物种果蝇和果蝇，沿一个纬度相互替换的不同耐热性的遗传基础，我们在两个物种的多个菌株中鉴定了hsp70基因簇。在这两个物种中，所有hsp70拷贝都聚集在一个染色体位点29C1中，每个簇都包含两个hsp70基因，它们成对排列，即祖先状态。在耐热性较差的D. virilis中，hsp70拷贝的总数最大为七个，而在较低耐热性的D. lummei中最大为五个，每种物种的某些菌株的拷贝数较低。因此，最大的hsp70拷贝数对应于先前报道的hsp70 mRNA和Hsp70蛋白水平以及29C1时热诱导的粉扑的大小。 hsp70拷贝的核苷酸序列和间隔与在D. virilis和D. lummei的共同祖先中的hsp70基因的串联复制一致，随后在lummei lummei中丢失了hsp70基因。果蝇中hsp70的这些和其他数据表明，进化适应通过几种不同的遗传机制反复修饰了hsp70的拷贝数。

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  • 来源
    《Chromosoma》 |2004年第5期|223-232|共10页
  • 作者

    Michael B. Evgen’ev; Olga G. Zatsepina; David Garbuz; Daniel N. Lerman; Vera Velikodvorskaya; Elena Zelentsova; Martin E. Feder;

  • 作者单位

    Engelhardt Institute of Molecular Biology Russian Academy of SciencesInstitute of Cell Biophysics;

    Engelhardt Institute of Molecular Biology Russian Academy of Sciences;

    Engelhardt Institute of Molecular Biology Russian Academy of Sciences;

    The Committee on Evolutionary Biology The University of Chicago;

    Institute of Cell Biophysics;

    Engelhardt Institute of Molecular Biology Russian Academy of Sciences;

    The Committee on Evolutionary Biology The University of ChicagoDepartment of Organismal Biology and Anatomy The Committees on Genetics and on Evolutionary Biology The University of Chicago;

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