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Biocatalyst enhancement

机译：生物催化剂的增强

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The increasing availability of enzyme collections has assisted attempts by pharmaceutical producers to adopt green chemistry approaches to manufacturing. A joint effort between an enzyme producer and a pharmaceutical manufacturer has been enhanced over the past three years by enabling process chemists to screen and optimize candidate enzymes from a panel of enzymes of a specific class. Enzyme chemistries tested in this enterprise included ene reductases, ketoreductases, transaminases, acylases, and halohydrin dehalogenases. Typical applications could involve the enantioselective reduction of ketones to chiral alcohols. The enzymes selected for the collections are easy to manufacture at large scale and exhibit robust activity across process conditions such as solvent concentration, pH, and temperature. The close collaboration between parties has assisted the enzyme selection, process optimization and conversion. With the success of the collaboration, the process chemists are enabled to consider the potential of enzyme mediated conversion processes.
机译：越来越多的酶收集物帮助制药商尝试采用绿色化学方法进行生产。在过去的三年中，通过使过程化学家能够从一组特定类别的酶中筛选和优化候选酶，增强了酶生产商和制药商之间的共同努力。该企业测试的酶化学试剂包括烯还原酶，酮还原酶，转氨酶，酰化酶和卤代醇脱卤酶。典型的应用可能涉及将酮对映选择性还原为手性醇。选择用于收集的酶易于大规模生产，并且在整个过程条件（例如溶剂浓度，pH和温度）下均显示出强大的活性。各方之间的密切合作有助于酶的选择，工艺优化和转化。随着合作的成功，过程化学家能够考虑酶介导的转化过程的潜力。

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  • 来源
    《Clean technologies and environmental policy》 |2009年第2期|147-151|共5页
  • 作者

    John A. Glaser;

  • 作者单位

    National Risk Management Research Laboratory,rnUS Environmental Protection Agency,rn26 W King Dr. Cincinnati, OH 45268, USA;

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