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Estimating the Burden of 2009 Pandemic Influenza A (H1N1) in the United States (April 2009–April 2010)

机译:估算美国2009年甲型H1N1大流行的负担(2009年4月至2010年4月)

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摘要

To calculate the burden of 2009 pandemic influenza A (pH1N1) in the United States, we extrapolated from the Centers for Disease Control and Prevention's Emerging Infections Program laboratory-confirmed hospitalizations across the entire United States, and then corrected for underreporting. From 12 April 2009 to 10 April 2010, we estimate that approximately 60.8 million cases (range: 43.3–89.3 million), 274 304 hospitalizations (195 086–402 719), and 12 469 deaths (8868–18 306) occurred in the United States due to pH1N1. Eighty-seven percent of deaths occurred in those under 65 years of age with children and working adults having risks of hospitalization and death 4 to 7 times and 8 to 12 times greater, respectively, than estimates of impact due to seasonal influenza covering the years 1976–2001. In our study, adults 65 years of age or older were found to have rates of hospitalization and death that were up to 75% and 81%, respectively, lower than seasonal influenza. These results confirm the necessity of a concerted public health response to pH1N1.
机译:为了计算美国2009年甲型大流行性流感(pH1N1)的负担,我们从疾病控制与预防中心的新兴感染计划中心在整个美国的实验室确认的住院病例中推断出数据,然后针对漏报进行了校正。从2009年4月12日到2010年4月10日,我们估计美国大约有6080万例(范围:43.3-89.3百万),274 304例住院(195 086-402 719)和12 469例死亡(8868-18 306)死亡。由于pH1N1而导致的状态。 87%的死亡发生在65岁以下的儿童和成年人中,其住院和死亡风险分别比1976年季节性流感造成的影响估计高4至7倍和8至12倍–2001年。在我们的研究中,发现65岁以上的成年人的住院率和死亡率分别比季节性流感低75%和81%。这些结果证实了对pH1N1采取协调一致的公共卫生措施的必要性。

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