• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Infectious Diseases >Rate of Infectious Complications during Interferon-Based Therapy for Hepatitis C Is Not Related to Neutropenia
【24h】

Rate of Infectious Complications during Interferon-Based Therapy for Hepatitis C Is Not Related to Neutropenia

机译：基于干扰素的丙型肝炎治疗期间感染并发症的发生率与中性粒细胞减少无关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The relationship between infectious complications and neutropenia was evaluated in recipients of interferon-based therapy for hepatitis C followed at The Ottawa Hospital Viral Hepatitis Clinic from June 2000 to May 2005. One hundred ninety-two patients received 211 courses of therapy (5707 person-weeks of therapy). No patients received granulocyte colony-stimulating factor. Sixty-seven infectious complications occurred in 57 patients (1.17 infections per 100 person-weeks of therapy). The median time to infection was 17 weeks after the start of therapy. Age, sex, weight, race, human immunodeficiency virus status, stage and grade of biopsy, and type of interferon were not correlated with infection rate by Cox regression analysis. The rates of total, fungal, viral, and bacterial infections did not correlate with nadir neutrophil count or magnitude of decrease from baseline. Neutrophil count is not correlated with infection rate in recipients of interferon-based therapy for hepatitis C. Reduction in interferon dose and/or dosing with granulocyte colony-stimulating factor in those with neutropenia is not supported by this analysis.
机译：在2000年6月至2005年5月于渥太华医院病毒性肝炎诊所接受了以干扰素为基础的丙型肝炎治疗的接受者中，评估了感染并发症和中性粒细胞减少之间的关系。192例患者接受了211疗程的治疗（5707人周治疗）。没有患者接受粒细胞集落刺激因子。 57例患者发生67例感染并发症（每100人-周治疗1.17例感染）。感染的中位时间为治疗开始后的17周。通过Cox回归分析，年龄，性别，体重，种族，人类免疫缺陷病毒状态，活检的阶段和等级以及干扰素的类型与感染率无关。总感染，真菌感染，病毒感染和细菌感染的发生率与最低嗜中性粒细胞计数或基线下降幅度均不相关。在以干扰素为基础的丙型肝炎治疗接受者中，中性粒细胞计数与感染率无关。该分析不支持降低中性粒细胞减少症患者的干扰素剂量和/或粒细胞集落刺激因子剂量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号