Women Infected with HIV Type 1 Brazilian Variant, Subtype B (B′-GWGR Motif) Have Slower Progression to AIDS, Compared with Patients Infected with Subtype B (B-GPGR Motif)

Adriana de Brito; Shirley C. V. Komninakis; Patrícia Novoa; Rafael M. de Oliveira; Luiz Augusto M. Fonseca; Alberto J. S. Duarte; and Jorge Casseb

首页> 外文期刊>Clinical Infectious Diseases >Women Infected with HIV Type 1 Brazilian Variant, Subtype B (B′-GWGR Motif) Have Slower Progression to AIDS, Compared with Patients Infected with Subtype B (B-GPGR Motif)

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Women Infected with HIV Type 1 Brazilian Variant, Subtype B (B′-GWGR Motif) Have Slower Progression to AIDS, Compared with Patients Infected with Subtype B (B-GPGR Motif)

机译：与感染B型（B-GPGR主题）的患者相比，感染了1型HIV巴西变异体B型（B'-GWGR主题）的女性患艾滋病的进程更慢

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Introduction. The Brazilian variant of human immunodeficiency virus (HIV) type 1 (HIV-1) subtype B (serotype B′-GWGR) has a tryptophan replacing a proline in position 328 of the HIV-1 envelope, a feature that may induce a different HIV disease progression. We aimed to evaluate the role of the B subtypes of HIV-1 (serotypes B-GPGR and B′-GWGR) on HIV disease progression.

机译：介绍。巴西的1型人类免疫缺陷病毒（HIV）亚型B（血清型B'-GWGR）的变体在HIV-1包膜的328位具有一个色氨酸替代脯氨酸，这一特征可能诱发不同的HIV疾病进展。我们旨在评估HIV-1的B亚型（血清型B-GPGR和B'-GWGR）在HIV疾病进展中的作用。

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《Clinical Infectious Diseases》 |2006年第11期|1476-1481|共6页
作者
Adriana de Brito; Shirley C. V. Komninakis; Patrícia Novoa; Rafael M. de Oliveira; Luiz Augusto M. Fonseca; Alberto J. S. Duarte; and Jorge Casseb;
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作者单位

Laboratory of Allergy and Clinical and Experimental Immunology São Paulo Brazil;

Department of Preventive Medicine University of São Paulo Medical School São Paulo Brazil;

Institute of Infectious Diseases Emílio Ribas São Paulo Brazil;

Federal University of São Paulo São Paulo Brazil;

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1. HIV disease progression: is the Brazilian variant subtype B' (GWGR motif) less pathogenic than US/European subtype B (GPGR)? [J] . Jorge Casseb, Shirley Komninakis, Leslie Abdalla, International journal of infectious diseases : . 2002,第3期

机译：HIV疾病进展：巴西变异B'亚型（GWGR基序）的致病性低于美国/欧洲B亚型（GPGR）吗？
2. Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02-AG compared with sub-subtype A3 [J] . PalmA.A., Esbj?rnssonJ., M?nssonF., The Journal of Infectious Diseases . 2014,第5期

机译：与亚亚型A3相比，感染重组HIV-1 A3 / CRF02-AG的血清事件个体更快地发展为AIDS和与AIDS相关的死亡
3. Comparison of Drug Resistance Mutations and Their Interpretation in Patients Infected With Non-B HIV-1 Variants and Matched Patients Infected With HIV-1 Subtype B. [J] . Segondy M JAIDS: Journal of acquired immune deficiency syndromes . 2004,第4期

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4. Transmissibility and Disease Progression in Groups of Individuals Infected with Different HIV-1 Subtypes in Cuba [C] . H.M. Diaz, A.L. Lubian, M. Blanco International AIDS Conference . 2004

机译：在古巴的不同HIV-1亚型感染的个体中的传染性和疾病进展
5. Differing symptom presentations of depression as a barrier to treatment for HIV/AIDS infected African-American women. [D] . Postell, Jacquelyn. 2011

机译：抑郁症的不同症状表现是感染艾滋病毒/艾滋病的非裔美国妇女的治疗障碍。
6. High prevalence of neutralizing activity against multiple unrelated human immunodeficiency virus type 1 (HIV-1) subtype B variants in sera from HIV-1 subtype B-infected individuals: evidence for subtype-specific rather than strain-specific neutralizing activity [O] . Marit J. van Gils, Diana Edo-Matas, Becky Schweighardt, -1

机译：来自HIV-1亚型B感染个体的血清中针对多种不相关的人类免疫缺陷病毒1型（HIV-1）B亚型变体的中和活性普遍存在：有亚型特异性而不是菌株特异性中和活性的证据
7. HIV disease progression: is the Brazilian variant subtype B' (GWGR motif) less pathogenic than US/European subtype B (GPGR)? [O] . Casseb Jorge, Komninakis Shirley, Abdalla Leslie, 2002

机译：HIV疾病进展：巴西变异B'亚型（GWGR基序）的致病性低于美国/欧洲B亚型（GPGR）吗？

Women Infected with HIV Type 1 Brazilian Variant, Subtype B (B′-GWGR Motif) Have Slower Progression to AIDS, Compared with Patients Infected with Subtype B (B-GPGR Motif)

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