Novel Targets for Drugs in Schizophrenia

J.M. Stone L.S. Pilowsky

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Novel Targets for Drugs in Schizophrenia

机译：精神分裂症药物的新型靶点

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Since the discovery of the first antipsychotic drug, chlorpromazine, in the early 1950s, all effective antipsychotic drugs have been found to share the common property of dopamine D2 receptor antagonism. There has been some suggestion that simple D2 receptor antagonism may not confer optimal antipsychotic efficacy. Currently available antipsychotic drugs leave many symptoms of the illness untreated and cause unacceptable side effects. Recent research in schizophrenia suggests a number of potential new non-D2 targets for pharmacotherapy including glutamate, acetylcholine and serotonin neurotransmitter systems. This review summarises the main neurochemical theories of schizophrenia, and, in the light of these, examines possible therapeutic targets for new antipsychotic drugs.

机译：自从1950年代初发现第一种抗精神病药物氯丙嗪以来，所有有效的抗精神病药物都被发现具有多巴胺D2受体拮抗作用的共同特性。有一些建议表明，简单的D2受体拮抗作用可能无法赋予最佳的抗精神病功效。当前可用的抗精神病药使许多疾病症状得不到治疗，并引起不可接受的副作用。精神分裂症的最新研究表明，许多潜在的药物治疗新的非D2靶标包括谷氨酸，乙酰胆碱和5-羟色胺神经递质系统。这篇综述总结了精神分裂症的主要神经化学理论，并据此审查了新型抗精神病药物的可能治疗靶标。

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来源
《CNS & Neurological Disorders - Drug Targets》 |2007年第4期|p.265-272|共8页
作者
J.M. Stone L.S. Pilowsky;
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作者单位

Section of Neurochemical Imaging, Kings College London Institute of Psychiatry, De Crespigny Park,London, SE5 8AF, UK.;

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正文语种 eng
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关键词
Schizophrenia, antipsychotic, dopamine, glutamate, NMDA, AMPA, acetylcholine, serotonin;

机译：精神分裂症;抗精神病药;多巴胺;谷氨酸;NMDA;AMPA;乙酰胆碱;5-羟色胺;

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2. Schizophrenia drug discovery and development in an evolving era: Are new drug targets fulfilling expectations? [J] . Dunlop John, Brandon Nicholas J. Journal of psychopharmacology . 2015,第2期

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6. A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case [O] . Liang-Chin Huang, Ergin Soysal, W Jim Zheng, 2015

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机译：加权和整合的药物-靶标相互作用组：针对精神分裂症的药物替代用途

Novel Targets for Drugs in Schizophrenia

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