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首页> 外文期刊>Cognitive Neuropsychiatry >The positive symptoms of acute schizophrenia and latent inhibition in humans and animals: Underpinned by the same process(es)?
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The positive symptoms of acute schizophrenia and latent inhibition in humans and animals: Underpinned by the same process(es)?

机译：人类和动物的急性精神分裂症的积极症状和潜在的抑制作用：是否以相同的过程为基础？

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Introduction. It has been suggested that the positive symptoms of acute schizophrenia are a consequence of a disruption of the process that produces latent inhibition (slower acquisition of conditioned responding after preexposure to the conditioned stimulus) and that this effect can be modelled by pro- and antipsychotic compounds in healthy participants and in nonhuman animals. This idea assumes that latent inhibition in humans and animals is underpinned by the same process(es). Method. First, we question the equivalence of human and animal latent inhibition. Second, we review the studies that have examined latent inhibition in populations with schizophrenia and in healthy populations after administration of amphetamine or haloperidol. Results. Theoretical analysis of the similarities and differences in latent inhibition effects, and the procedures used to generate them, in humans and animals renders the suggested equivalence between them unconvincing. The studies examining latent inhibition in populations with schizophrenia and in healthy populations after administration of amphetamine or haloperidol are marked by a number of methodological shortcomings and reveal discrepant results. Conclusions. The theoretical and empirical analyses provide little support for a common process underlying deficits of latent inhibition in patients exhibiting positive symptoms of acute schizophrenia, and such deficits in experimental models in healthy humans and infrahumans.View full textDownload full textKeywordsAmphetamine, Antipsychotic agents, Association learning, HaloperidolRelated var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; var addthis_config = {"data_track_addressbar":true,"ui_click":true}; Add to shortlist Link Permalink http://dx.doi.org/10.1080/13546805.2012.667202
机译：介绍。有人认为，急性精神分裂症的阳性症状是产生潜在抑制作用的过程中断的结果（预先暴露于条件刺激后，条件响应反应的获得较慢），这种作用可以用抗精神病药和抗精神病药模拟在健康的参与者和非人类动物中。这个想法假设人类和动物潜在的抑制作用是由相同的过程所支撑的。方法。首先，我们质疑人类和动物潜在抑制的等效性。其次，我们回顾了研究了苯丙胺或氟哌啶醇给药后在精神分裂症人群和健康人群中潜在抑制作用的研究。结果。对人和动物中潜在抑制作用的相似性和差异以及产生它们的程序进行理论分析，使它们之间的等效性难以令人信服。在苯丙胺或氟哌啶醇给药后检查精神分裂症人群和健康人群潜在抑制作用的研究存在许多方法学缺陷，并显示出不同的结果。结论。理论和经验分析几乎不支持表现出急性精神分裂症阳性症状的患者潜在抑制缺陷的常见过程，以及健康人和亚人类的实验模型中的这种缺陷。查看全文下载全文关键词HaloperidolRelated var addthis_config = {ui_cobrand：“泰勒和弗朗西斯在线”，services_compact：“ citlikelike，netvibes，twitter，technorati，delicious，linkedin，facebook，stumbleupon，digg，google，more”，pubid：“ ra-4dff56cd6bb1830b”}; var addthis_config = {“ data_track_addressbar”：true，“ ui_click”：true};添加到候选列表链接永久链接http://dx.doi.org/10.1080/13546805.2012.667202

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