Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

Mads P.G. Korsgaard Dorte Strobaek Palle Christophersen

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Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

机译：药物发现中的自动平面电极电生理学：在Nav，KCa2.3和Kv11.1通道的基本表征和高内涵筛选中使用QPatch的示例

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Planar chip technology has strongly facilitated the progress towards fully automated electrophysiological systems that, in contrast to the traditional patch clamp technology, have the capability of parallel compound testing. The throughput has been increased from testing below 10 compounds per day to a realized capacity approaching high throughput levels. Many pharmaceutical companies have implemented automated planar chip electrophysiology in their drug discovery process, particularly at the levels of lead optimization, secondary screening and safety testing, whereas primary screening is generally not performed. In this review, we briefly discuss the technology and give examples from selected NeuroSearch ion channel programs, where one of the systems, the QPatch, has been evaluated for use in lead optimization and primary screening campaigns, where high information content was a requirement.

机译：平面芯片技术极大地推动了向全自动电生理系统的发展，与传统的膜片钳技术相比，该系统具有并行化合物测试的能力。吞吐量已从每天测试少于10种化合物增加到接近高吞吐量水平的已实现容量。许多制药公司已经在其药物发现过程中实现了自动化的平面芯片电生理学，特别是在铅优化，二级筛选和安全性测试方面，而通常不进行一级筛选。在这篇综述中，我们简要讨论了该技术，并从选定的NeuroSearch离子通道程序中提供了示例，其中已评估了其中一个系统QPatch用于铅优化和主要筛选活动，而这些活动要求高信息量。

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《Combinatorial Chemistry & High Throughput Screening》 |2009年第1期|p.51-63|共13页
作者
Mads P.G. Korsgaard Dorte Strobaek Palle Christophersen;
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作者单位

NeuroSearch A/S, Pederstrupvej 93, DK 2750 Ballerup, Denmark.;

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原文格式 PDF
正文语种 eng
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关键词
channels,electrophysiology, channels;

机译：通道;电生理学;通道;

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专利

1. Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels. [J] . Korsgaard MP, Strobaek D, Christophersen P Combinatorial chemistry & high throughput screening . 2009,第1期

机译：药物发现中的自动平面电极电生理学：在Na（v），K（Ca）2.3和K（v）11.1通道的基本表征和高含量筛选中使用QPatch的示例。
2. Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms. [J] . Castle N, Printzenhoff D, Zellmer S, Combinatorial chemistry & high throughput screening . 2009,第1期

机译：使用自动高通量电生理平台发现钠通道抑制剂药物。
3. Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms [J] . Neil Castle David Printzenhoff Shannon Zellmer Brett Antonio Alan Wickenden Christopher Silvia Combinatorial Chemistry & High Throughput Screening . 2009,第1期

机译：使用自动高通量电生理平台的钠通道抑制剂药物发现
4. Image analysis methods in high-content screening for phenotypic drug discovery [C] . Vorontsova Elena, Solovieva Anastasiya 2017 International Multi-Conference on Engineering, Computer and Information Sciences . 2017

机译：高水平筛选表型药物发现的图像分析方法
5. Automated Electrophysiology Makes the Pace for Cardiac Ion Channel Safety Screening [O] . Clemens Möller, Harry Witchel 2011

机译：自动化的电生理学为心脏离子通道安全性筛查奠定了基础
6. Automated Patch Clamp Electrophysiology Enables the Differentiation of Compound Mode of Action at Nav Channels [O] . Baxter Andrew W., Downie David, Powell Andrew J. 2010

机译：自动化的膜片钳电生理学可区分Nav通道的复合作用模式

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

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