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首页> 外文期刊>Combinatorial Chemistry & High Throughput Screening >Editorial [Hot Topic: Antimicrobial Peptides (Guest Editor: Alexander Cole)]
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Editorial [Hot Topic: Antimicrobial Peptides (Guest Editor: Alexander Cole)]

机译：社论[热门话题：抗菌肽（来宾编辑：Alexander Cole）]

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摘要

The urgent need to develop new antibiotics has been a major force behind the advancement of antimicrobial peptides asntherapeutics and preventatives. Over the last decade, there have been significant improvements in methodology that arenessential to drive the evolution of peptides into marketable drugs. The development of sensitive, high-throughput tools tonscreen libraries of peptide compounds has enabled the discovery of next-generation molecules active against a broad spectrumnof microbes. By looking at the effect that peptide compounds have on the protein expression of both the host and thenpathogen, the fields of genomics and proteomics have been invaluable resources in the discovery process. More recently,ncombinatorial chemistry has played an increasing role in the design of next-generation peptides. Much like current combinationnantibiotic treatments, ‘designer peptides’ could likely emerge, whereby antimicrobial peptide cocktails would be formulatednspecific to each pathogen. However, the convergence of the aforementioned technologies is still in its infancy, and thus it maynstill be too soon to know how antimicrobial peptides come to meeting the specifications of agents for topical or systemicnadministration.
机译：迫切需要开发新的抗生素，一直是抗菌肽作为治疗和预防手段发展的主要力量。在过去的十年中，在驱动肽向市售药物发展的方法学上有了重大改进。肽化合物灵敏，高通量工具吨筛选文库的开发使发现对多种微生物具有活性的下一代分子成为可能。通过观察肽化合物对宿主和病原体两者蛋白质表达的影响，基因组学和蛋白质组学领域已成为发现过程中的宝贵资源。最近，组合化学在下一代肽的设计中起着越来越重要的作用。与目前的抗生素组合治疗很像，“设计肽”可能会出现，从而可以针对每种病原体制定抗菌肽混合物。但是，上述技术的融合仍处于起步阶段，因此，了解抗菌肽如何满足局部或全身给药的药剂规格仍为时过早。

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  • 作者

    Alexander M. Cole;

  • 作者单位

    Department of Molecular Biology and MicrobiologyBiomolecular Science CenterBurnett College of Biomedical SciencesUniversity of Central FloridaBldg. 20, Rm. 2364000 Central Florida Blvd.Orlando, FL 32816-2364USAE-mail: acole@mail.ucf.edu;

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  • 正文语种 eng
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  • 关键词

    antibiotics;

    机译：抗生素类;

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