Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

Christopher G. Adda Robin F. Anders Leann Tilley Michael Foley

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Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

机译：在噬菌体上显示的随机序列文库：生物重要分子的鉴定。

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Phage display has become a widely used tool for the identification of proteins or peptides with affinity for a variety of biomolecules. The versatility, simplicity and cost effectiveness of this application has pervaded a wide variety of research areas. Although not without its limitations, phage display has provided a convenient methodology for obtaining ligands to study the function, structure and diagnostic or therapeutic potential of various macromolecules. This review highlights some recent research employing this technology that serves to illustrate its utility in various research and clinical applications.

机译：噬菌体展示已成为鉴定对多种生物分子具有亲和力的蛋白质或肽的一种广泛使用的工具。此应用程序的多功能性，简便性和成本效益已经遍及广泛的研究领域。尽管并非没有限制，但噬菌体展示提供了一种方便的方法来获得配体，以研究各种大分子的功能，结构以及诊断或治疗潜力。这篇综述重点介绍了采用该技术的一些最新研究，以说明其在各种研究和临床应用中的效用。

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《Combinatorial Chemistry & High Throughput Screening》 |2002年第1期|p.1-14|共14页
作者
Christopher G. Adda Robin F. Anders Leann Tilley Michael Foley;
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作者单位

Department of Biochemistry, La Trobe University, Bundoora, Victoria, 3083 Australia;

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正文语种 eng
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关键词
Phage display, biopannig, tissue-type plasminogen activator;

机译：噬菌体展示;生物panigig;组织型纤溶酶原激活剂;

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专利

1. Random sequence libraries displayed on phage: identification of biologically important molecules. [J] . Adda CG, Anders RF, Tilley L, Combinatorial chemistry & high throughput screening . 2002,第1期

机译：噬菌体上展示的随机序列文库：生物学重要分子的鉴定。
2. Scavenger receptor block as strategy for the identification of bone marrow homing phages by panning in vivo random peptide phage displayed libraries. [J] . Finger AN, Bisoffi M, Wetterwald A, Journal of Immunological Methods . 2002,第1a2期

机译：清道夫受体阻滞作为通过淘选体内随机肽噬菌体展示文库鉴定骨髓归巢噬菌体的策略。
3. T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries [J] . Krumpe LR, Atkinson AJ, Smythers GW, Proteomics . 2006,第15期

机译：T7裂解性噬菌体展示的肽库比M13丝状噬菌体展示的肽库表现出更少的序列偏向
4. Isolation and characterization of human IgA-specific binding peptides from random peptide library on T7 phage display system [C] . Takaaki Hatanaka, Sayaka Kakoi, Ryohei Sugita Japanese peptide symposium . 2011

机译：T7噬菌体显示系统随机肽文库中人IGA特异性结合肽的分离与表征
5. Identification and characterization of surrogate peptide ligands for Mas, an orphan G protein-coupled receptor, using phage-displayed random peptide library. [D] . Bikkavilli, Rama Kamesh. 2005

机译：使用噬菌体展示的随机肽库，鉴定和表征Mas（孤儿G蛋白偶联受体）的替代肽配体。
6. Evolutional selection of a combinatorial phage library displaying randomly-rearranged various single domains of immunoglobulin (Ig)-binding proteins (IBPs) with four kinds of Ig molecules [O] . Hua Yang, Jie Cao, Lian-Qing Li, 2008

机译：展示具有四种Ig分子的随机重新排列的免疫球蛋白（Ig）结合蛋白（IBPs）各个单个域的组合噬菌体库的进化选择
7. Evolutional selection of a combinatorial phage library displaying randomly-rearranged various single domains of immunoglobulin (Ig)-binding proteins (IBPs) with four kinds of Ig molecules [O] . Jia Jian-An, Xu Rong, Jiang Shao-Hua, 2008

机译：展示具有四种Ig分子的随机重新排列的免疫球蛋白（Ig）结合蛋白（IBPs）各个单个域的组合噬菌体库的进化选择

Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

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