Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents

T. Mineno K.M. Stanford L.A. Walker M.A. Avery

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Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents

机译：异黄酮文库的溶液相平行合成用于发现新型抗疟药

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Combinatorial chemistry has become a dramatically useful tool for the development of new medicinal agents. In the search to discover a novel and effective lead for the treatment of giardiasis, solutionphase synthesis of a library of isoflavone derivatives has been accomplished. Of the products screened, several compounds such as P(A1,B1) and P(A1,B11) exhibited potent antigiardial activity. The details of synthesis, in vitro antigiardial assay, and preliminary structure-activity relationships of these compounds are described.

机译：组合化学已成为开发新药物的极为有用的工具。为了发现用于治疗贾第鞭毛虫病的新颖有效的先导，已经完成了异黄酮衍生物文库的溶液相合成。在筛选出的产品中，几种化合物（例如P（A1，B1）和P（A1，B11））表现出强大的抗多糖活性。描述了这些化合物的合成，体外抗微生物测定以及初步结构-活性关系的详细信息。

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《Combinatorial Chemistry & High Throughput Screening》 |2002年第6期|p.481-487|共7页
作者
T. Mineno K.M. Stanford L.A. Walker M.A. Avery;
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作者单位

Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677, USA.;

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原文格式 PDF
正文语种 eng
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关键词
Combinatorial chemistry,medicinal agents,treatment of giardiasis;

机译：组合化学;药物;贾第鞭毛虫病的治疗;

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1. Solution-phase parallel synthesis of an isoflavone library for the discovery of novel antigiardial agents. [J] . Mineno T, Stanford KM, Walker LA, Combinatorial chemistry & high throughput screening . 2002,第6期

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Solution-Phase Parallel Synthesis of an Isoflavone Library for the Discovery of Novel Antigiardial Agents

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