The present minireview deals with the use of the oxidative properties of copper(II/I) coordination compounds for valuable applications, namely the selective conversion of alcohols into aldehydes (or ketones), the cleavage of DNA strands (anti-cancer drugs), and the prevention of the formation of copper/amyloid plaques in Alzheimer's disease (AD). The concise report is therefore organized in three clearly defined parts: i) the design and preparation of simple copper(II) (and copper(I)) coordination compounds, mimicking the enzymatic activity of galactose oxidase, to mediate the selective oxidation of alcoholic substrates; ii) the generation of copper-containing chemical nucleases for the development of effective anti-cancer agents; iii) the current state of the art regarding the elucidation of the copper-based biological mechanisms (involving β-amyloid) that govern neural degeneration in AD.View full textDownload full textKeywordsAlzheimer, amyloid fibril, cancer, catalysis, DNA cleavage, galactose oxidase Related var addthis_config = { ui_cobrand: "Taylor & Francis Online", services_compact: "citeulike,netvibes,twitter,technorati,delicious,linkedin,facebook,stumbleupon,digg,google,more", pubid: "ra-4dff56cd6bb1830b" }; Add to shortlist Link Permalink http://dx.doi.org/10.1080/02603594.2011.642088
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