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首页> 外文期刊>Communications in Numerical Methods in Engineering >Computational simulations of the helical buckling behavior of blood vessels
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Computational simulations of the helical buckling behavior of blood vessels

机译：血管螺旋屈曲行为的计算模拟

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摘要

Tortuous vessels are often observed in vivo and could hinder or even disrupt blood flow to distal organs. Besides genetic and biological factors, the in vivo mechanical loading seems to play a role in the formation of tortuous vessels, but the mechanism for formation of helical vessel shape remains unclear. Accordingly, the aim of this study was to investigate the biomechanical loads that trigger the occurrence of helical buckling in blood vessels using finite element analysis. Porcine carotid arteries were modeled as thick-walled cylindrical tubes using generalized Fung and Holzapfel-Gasser-Ogden constitutive models. Physiological loadings, including axial tension, lumen pressure, and axial torque, were applied. Simulations of various geometric dimensions, different constitutive models at various levels of axial stretch ratios, lumen pressures, and twist angles were performed to identify the mechanical factors that determine the helical stability. Our results demonstrated that axial torsion can cause wringing (twist buckling) that leads to kinking or helical coiling and even looping and winding. The specific buckling patterns depend on the combination of lumen pressure, axial torque, axial tension, and the dimensions of the vessels. This study elucidates the mechanism of how blood vessels buckle under various mechanical loads and how complex mechanical loads yield helical buckling.
机译：经常在体内观察到曲折的血管，并且可能阻碍甚至破坏流向远端器官的血液。除遗传和生物学因素外，体内机械负荷似乎在曲折血管的形成中起作用，但螺旋血管形状形成的机制仍不清楚。因此，本研究的目的是使用有限元分析来研究触发血管螺旋屈曲发生的生物力学载荷。使用广义的Fung和Holzapfel-Gasser-Ogden本构模型将猪颈动脉建模为厚壁圆柱管。施加生理负荷，包括轴向张力，内腔压力和轴向转矩。对各种几何尺寸，不同本构模型进行了不同程度的轴向拉伸比，内腔压力和扭转角的仿真，以识别确定螺旋稳定性的机械因素。我们的结果表明，轴向扭转会导致扭曲（扭曲），从而导致扭结或螺旋形缠绕，甚至成环缠绕。具体的屈曲模式取决于管腔压力，轴向扭矩，轴向张力和血管尺寸的组合。这项研究阐明了在各种机械载荷下血管如何弯曲以及复杂的机械载荷如何产生螺旋屈曲的机理。

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