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首页> 外文期刊>Computers & Chemical Engineering >Quick identification of a simple enzyme deactivation model for an extended-Michaelis-Menten reaction type. Exemplification for the d-glucose oxidation with a complex enzyme deactivation kinetics
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Quick identification of a simple enzyme deactivation model for an extended-Michaelis-Menten reaction type. Exemplification for the d-glucose oxidation with a complex enzyme deactivation kinetics

机译：快速识别扩展的Michaelis-Menten反应类型的简单酶失活模型。具有复杂酶失活动力学的d-葡萄糖氧化的示例

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摘要

One essential engineering problem when developing an industrial enzymatic process concerns the model-based design and optimal operation of the enzymatic reactor based on the process and enzyme inactivation kinetics. For a complex enzymatic system, the "default" used first-order enzyme deactivation model has been proved to lead to inadequate process design or sub-optimal operating policies. The present study investigates if a complex enzyme deactivation can be approximated with simple 1 st, 2nd, or a novel proposed model with variable deactivation constant. The approached complex enzymatic system is those of the oxidation of d-glucose to 2-keto-d-glucose in the presence of pyranose 2-oxidase. The necessary "simulated experimental data" have been generated by means of an extended kinetic model from literature used to simulate a batch reactor under well-defined nominal conditions. The proposed enzyme deactivation model has been found to be the best lumping alternative, presenting several advantages: simplicity, flexibility, and a very good adequacy.
机译：在开发工业酶促工艺时，一个基本工程问题涉及基于模型的设计以及基于工艺和酶灭活动力学的酶促反应器的最佳操作。对于复杂的酶系统，已证明使用“默认”的一阶酶失活模型会导致工艺设计不足或操作策略欠佳。本研究调查了复杂的酶失活是否可以用简单的第一，第二或具有可变失活常数的新提出的模型来近似。所接近的复杂酶系统是在吡喃糖2-氧化酶存在下将d-葡萄糖氧化为2-酮-d-葡萄糖的那些。必要的“模拟实验数据”已经通过文献的扩展动力学模型生成，该模型用于在定义明确的标称条件下模拟间歇式反应器。已发现拟议的酶失活模型是最佳的集总替代方案，具有多个优点：简单，灵活和非常合适。

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