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首页> 外文期刊>Computers & Structures >In vivo MRI-based 3D FSI RV/LV models for human right ventricle and patch design for potential computer-aided surgery optimization
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In vivo MRI-based 3D FSI RV/LV models for human right ventricle and patch design for potential computer-aided surgery optimization

机译：基于体内MRI的3D FSI RV / LV模型用于右心室和贴片设计，可用于潜在的计算机辅助手术优化

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摘要

Right ventricular dysfunction is one of the more common causes of heart failure in patients with congenital heart defects. Use of computer-assisted procedures is becoming more popular in clinical decision making process and computer-aided surgeries. A 3D in vivo MRI-based RV/LV combination model with fluid-structure interaction (FSI), RV-LV interaction, and RV-patch interaction was introduced to perform mechanical analysis for human right ventricle with potential clinical applications. Patient-specific RV/LV morphologies were acquired by using planar tagged MRI. The 3D RV/LV FSI model was solved using a commercial finite element package ADINA. Our results indicated that flow and stress/strain distributions in the right ventricle are closely related to RV morphology, material properties and blood pressure conditions. Patches with material properties better matching RV tissue properties and smaller size lead to better RV function recoveries. Computational RV volumes'showed very good agreement with MRI data (error < 3%). More patient studies are needed to establish baseline database so that computational simulations can be used to replace empirical and often risky clinical experimentation to examine the efficiency and suitability of various reconstructive procedures in diseased hearts and optimal design can be found.
机译：右心功能不全是先天性心脏病患者心力衰竭的较常见原因之一。在临床决策过程和计算机辅助手术中，计算机辅助程序的使用正变得越来越普遍。引入了基于3D体内MRI的RV / LV组合模型，该模型具有流体-结构相互作用（FSI），RV-LV相互作用和RV-膜片相互作用，可以对具有潜在临床应用的右心室进行机械分析。通过使用平面标记MRI获得患者特定的RV / LV形态。 3D RV / LV FSI模型使用商业有限元软件包ADINA求解。我们的结果表明右心室中的流量和应力/应变分布与RV形态，材料特性和血压状况密切相关。具有与RV组织特性更好匹配的材料特性的贴片和较小的尺寸可导致更好的RV功能恢复。计算出的RV体积与MRI数据非常吻合（误差<3％）。建立基线数据库需要更多的患者研究，以便可以使用计算模拟来代替经验性和通常有风险的临床实验，以检查患病心脏中各种重建程序的效率和适用性，并找到最佳设计。

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