Fluid-structure modeling of flow-induced alveolar epithelial cell deformation

H.L. Dailey; H.C. Yalcin; S.N. Ghadiali

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Fluid-structure modeling of flow-induced alveolar epithelial cell deformation

机译：流动引起的肺泡上皮细胞变形的流体结构建模

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Fluid buildup in the small pulmonary airways can exert injurious stresses on the epithelial cells which line airway walls. Under these conditions, the amount of deformation-induced cell injury may depend on the magnitude of the hydrodynamic stresses and the cells' mechanical properties. In this study, we present 2D and 3D fluid-structure interaction models of flow-induced cell deformation. We report wall shear stress on the cells and cell membrane strain for a range of cell and membrane stiffness values. Results indicate that more compliant cells experience lower wall shear stresses but higher membrane strains. We correlate our results to experimental studies of cellular injury under airway reopening conditions and validate our computational method by comparison to an analytical solution of flow over a rigid protrusion in a channel.

机译：肺小气道中的液体积聚会在气道壁两侧的上皮细胞上施加伤害性压力。在这些条件下，变形引起的细胞损伤的程度可能取决于流体动力应力的大小和细胞的机械性能。在这项研究中，我们提出了流动引起的细胞变形的2D和3D流体-结构相互作用模型。我们报告了细胞和细胞膜应变对于一系列细胞和膜硬度值的壁切应力。结果表明，顺应性较高的细胞壁剪切应力较低，而膜应变较高。我们将我们的结果与气道重开条件下细胞损伤的实验研究进行关联，并通过与通道中刚性突起上的流动的解析解进行比较来验证我们的计算方法。

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来源
《Computers & Structures》 |2007年第14期|p.1066-1071|共6页
作者
H.L. Dailey; H.C. Yalcin; S.N. Ghadiali;
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作者单位

Mechanical Engineering and Mechanics, Lehigh University, Rm. 265 Packard Lab, 19 Memorial Drive West, Bethlehem, PA 18015, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类计算技术、计算机技术;
关键词
lung mechanics; epithelial cell; shear stress; membrane strain; deformation;

机译：肺力学;上皮细胞;剪切应力;膜应变;变形;

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Fluid-structure modeling of flow-induced alveolar epithelial cell deformation

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