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首页> 外文期刊>Coordination chemistry reviews >Competition between Cd(II) and other divalent transition metal ions during complex formation with amino acids, peptides, and chelating agents
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Competition between Cd(II) and other divalent transition metal ions during complex formation with amino acids, peptides, and chelating agents

机译：Cd（II）与其他二价过渡金属离子在与氨基酸，肽和螯合剂形成络合物期间的竞争

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Cadmium is not an essential element for humans, but instead its compounds are known for their toxicity. In addition to the risks for workers in industries that use cadmium, this metal can enter the food chain at different levels to be absorbed by the body, where it replaces other metals with similar chemical activity. This also applies to the cadmium inhaled via cigarette smoking. Thus, understanding the interactions between cadmium and biologically relevant molecules, such as amino acids, peptides, and proteins, is important, but it is also useful to study the chelating methods that can cure or alleviate acute or chronic cadmium poisoning cases. Cd-111/113 isotopes are used as NMR probes to determine the complex formation sites and geometry of metals in metalloproteins and metalloenzymes. This review provides a general introduction to the general properties of cadmium as well as the main uses of this metal, its compounds, and artifacts. The toxicity of cadmium in humans is also discussed and the most significant results regarding the interactions between cadmium and other potentially competing divalent metal ions with biological relevance, i.e. Fe(II), Zn(II), Mn(II), Ni(II), and Cu(II), and amino acids and peptides, particularly those containing histidine and/or thiolic groups, are collected. To the best of our knowledge, this is the most comprehensive summary reported for the speciation models of these systems. Distribution and competition diagrams were constructed to facilitate comparisons of the binding abilities of different metals with the same ligand (or vice versa) over a wide pH range and with different reagent concentrations and/or concentration ratios, thereby providing insights into the in vivo behavior both inside and outside cells where the pH and concentration can be very different. The vast topic of complexes with phytochelatins and metallothioneins is left for a more focused study. Finally, cadmium chelators with potential pharmacological applications are thoroughly reviewed. (C) 2016 Elsevier B.V. All rights reserved.
机译：镉不是人类必需的元素，但其化合物以其毒性而著称。除了使用镉的行业中的工人面临的风险外，这种金属还可以进入食物链的不同水平，从而被人体吸收，从而替代具有相似化学活性的其他金属。这也适用于通过吸烟吸入的镉。因此，了解镉与生物相关分子（例如氨基酸，肽和蛋白质）之间的相互作用非常重要，但研究可治愈或缓解急性或慢性镉中毒病例的螯合方法也很有用。 Cd-111 / 113同位素用作NMR探针，以确定金属蛋白和金属酶中金属的复杂形成部位和几何形状。这篇综述对镉的一般性质以及这种金属，其化合物和人工制品的主要用途进行了一般性介绍。还讨论了镉对人类的毒性，并且关于镉与其他具有生物学相关性的潜在竞争性二价金属离子（如Fe（II），Zn（II），Mn（II），Ni（II））之间的相互作用的最重要结果收集氨基酸和多肽，特别是含有组氨酸和/或巯基的氨基酸和多肽。据我们所知，这是这些系统的物种模型报告的最全面的摘要。构建分布图和竞争图以促进在宽pH范围内以及不同试剂浓度和/或浓度比的情况下比较不同金属与相同配体的结合能力（反之亦然），从而提供对体内行为的见解内部和外部细胞的pH值和浓度可能会非常不同。与植物螯合蛋白和金属硫蛋白复合物的广泛话题尚待进一步研究。最后，对具有潜在药理应用的镉螯合剂进行了全面审查。 （C）2016 Elsevier B.V.保留所有权利。

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