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Single-atom nanozymes: A rising star for biosensing and biomedicine

机译：单原子纳佐：一种用于生物腐蚀和生物医学的升级星

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摘要

Nanozymes with excellent and intrinsic enzyme-mimicking characteristics have been considered as extremely promising alternatives to natural enzymes due to their merits of low cost, easy storage, tunable catalytic activities, high stability, and easy large-scale production. Enormous efforts have been devoted to the development of highly efficient nanozymes and the promising applications of nanozymes. Recently, single-atom nanozymes (SAzymes) emerge as a novel high performance nanozyme and have attracted extensive study interests. Moreover, SAzymes with homogeneously dispersed active sites and well-defined coordination structures offer rare opportunities to explore their structure-activity relationship and regulate the geometric and electronic properties of catalytic active sites. By now, SAzymes have made impressive progresses in their design synthesis, mechanism study, and advanced applications. In this review, we comprehensively summarize the latest research advances on the design construction, catalytic mechanism, biosensing and biomedicine applications of SAzymes. First of all, the synthesis strategies (including wet-chemical synthesis, metal organic frameworks (MOFs)-derived strategy, and atom trapping strategy, etc.), active centers, and catalytic mechanism of SAzymes are considerately summarized. Then, the attentions are concentrated on their advanced applications, including biosensing and biomedicine applications (i.e., cancer therapy, antibacterial, cytoprotection, wound healing, and sepsis treatment). At the end of the article, the challenges and opportunities on the further studies of SAzymes (including design, synthesis, and surface modification, selectivity, catalytic activity, diversities, catalytic mechanism, and promising applications) are tentatively proposed. (C) 2020 Elsevier B.V. All rights reserved.
机译：具有优异和本质酶模拟特性的纳佐被认为是天然酶的极其有​​前途的替代品，因为它们的优点是其低成本，易储存，可调催化活动，高稳定性和易大规模的大规模生产。巨大的努力已经致力于高效的纳米酶的发展和纳释中有前途的应用。最近，单原子纳米酶（Sazymes）作为一种新型高性能纳佐中的纳佐，并引起了广泛的研究兴趣。此外，具有均匀分散的活性位点和定义的协调结构的山血小酵母提供了探讨其结构活动关系的罕见机会，并调节催化活性位点的几何和电子性质。到目前为止，Sazymes在设计合成，机制研究和先进应用方面取得了令人印象深刻的进展。在本综述中，我们全面总结了山唑的设计施工，催化机制，生物医学和生物医学应用的最新研究进展。首先，总结了合成策略（包括湿化学合成，金属有机框架（MOF）和原子捕获策略等），活跃的中心，活跃的中心和催化机制。然后，将注意力集中在其先进的应用上，包括生物沉积和生物医生应用（即癌症治疗，抗菌，细胞科，伤口愈合和败血症处理）。暂停文章结束时，暂时提出了对酶进一步研究的挑战和机遇（包括设计，合成和表面改性，选择性，催化活性，多样性，催化机制和有前途的应用）。 （c）2020 Elsevier B.v.保留所有权利。

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  • 来源
    《Coordination chemistry reviews》 |2020年第9期|213376.1-213376.23|共23页
  • 作者

    Zhang Xianlong; Li Guoliang; Chen Guang; Wu Di; Zhou Xuxia; Wu Yongning;

  • 作者单位

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian 710021 Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian 710021 Peoples R China|Qufu Normal Univ Key Lab Life Organ Anal Shandong Prov Qufu 273165 Shandong Peoples R China;

    Qufu Normal Univ Key Lab Life Organ Anal Shandong Prov Qufu 273165 Shandong Peoples R China;

    Queens Univ Belfast Sch Biol Sci Inst Global Food Secur 19 Chlorine Gardens Belfast BT9 5DL Antrim North Ireland;

    Zhejiang Univ Technol Dept Food Sci & Technol Hangzhou 310014 Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian 710021 Peoples R China|Chinese Acad Med Sci China Natl Ctr Food Safety Risk Assessment NHC Key Lab Food Safety Risk Assessment Food Safety Res Unit 2019RU014 Beijing 100021 Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Single-atom nanozymes; Catalytic mechanism; Biosensing; Cancer therapy; Antibacterial; Cytoprotection; Wound healing; Sepsis treatment;

    机译：单原子纳米酶;催化机制;生物传感;癌症疗法;抗菌;细胞保护;伤口愈合;败血症治疗;

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