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首页> 外文期刊>Coordination chemistry reviews >Pharmacological applications of non-radioactive indium(Ⅲ) complexes: A field yet to be explored
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Pharmacological applications of non-radioactive indium(Ⅲ) complexes: A field yet to be explored

机译：非放射性铟（Ⅲ）复合物的药理应用：尚未探索的领域

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摘要

Although radioactive In-111(III) compounds have been extensively investigated for labeling of cells in detection and diagnosis of infections and inflammation, the pharmacological applications of nonradioactive indium(III) complexes remain so far almost unexplored. In the present work the main potential applications of these complexes as antimicrobial and antineoplastic agents are reviewed, together with their interactions with different biomolecules. Some aspects of the behavior of indium(III) complexes in biological aqueous media are also mentioned. The interactions of indium(III) complexes with transferrin are discussed, with emphasis in the potential applications of these compounds for the treatment of tumors which overexpress transferrin receptors. Hence, the affinity of indium(III) complexes for transferrin might be explored in the design of selective antineoplastic agents. Some preliminary information on the toxicity of these complexes is given as well, which must be taken into consideration in evaluating the efficacy, safety and druggability of indium(III) complexes. Since In-111 compounds are already used in clinics, non-radioactive indium(III) complexes might be an attractive platform for developing novel metal-based antitumor drug candidates. (C) 2020 Elsevier B.V. All rights reserved.
机译：虽然放射性地In-111（III）化合物已被广泛研究用于在感染和炎症的检测和诊断中标记细胞，但迄今为止，非聚酰基活性铟（III）复合物的药理应用几乎是未开发的。在本工作中，将这些复合物作为抗微生物和抗肿瘤剂的主要潜在应用与其与不同生物分子的相互作用进行了综述。还提到了生物含水培养基中铟（III）复合物的行为的一些方面。讨论铟（III）复合物与转铁蛋白的相互作用，重点是这些化合物的潜在应用，用于治疗过表达转化素受体的肿瘤。因此，在选择性抗肿瘤剂的设计中可以探讨铟（III）复合物对转移素的亲和力。还给出了一些关于这些配合物的毒性的初步信息，必须考虑到评估铟（III）复合物的功效，安全性和可耐药性。由于111个化合物已经用于诊所，因此非放射性铟（III）复合物可能是开发新型金属基抗肿瘤候选者的有吸引力的平台。 （c）2020 Elsevier B.v.保留所有权利。

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