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Boron cluster compounds as new chemical leads for antimicrobial therapy

机译：硼簇化合物作为新化学物质的抗菌治疗

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摘要

Boron cluster compounds are inorganic compounds with chemical compositions and structures vastly different from those of organic compounds, albeit with the ability to form a rich family of molecules. Boron cluster compounds are 3-dimensional, aromatic compounds with 3-center-2-electron (3c2e) bonds (e.g., B-B-B and B-B-C). They are not found in living organisms, which explains the lack of enzymatic systems capable of metabolizing boron cluster compounds and their high biological stability. In addition, boron cluster compounds and organic compounds interact with components of biological systems, such as lipid membranes and proteins, through different mechanisms. As a result, derivatives of boron cluster compounds show the same efficacy against standard and multi-drug resistant strains of pathogens. Moreover, they show anti-biofilm activity and are less prone to trigger drug resistance. In conclusion, boron cluster compounds have the potential to become new chemical leads in antimicrobial therapy because their derivatives show promising antimicrobial activity and low sensitivity to both genetic and phenotypic mechanisms of pathogen resistance. (C) 2020 Elsevier B.V. All rights reserved.
机译：硼簇化合物是具有化学成分的无机化合物，并且与有机化合物大众差异不同，尽管具有形成丰富的分子系列的能力。硼簇化合物是具有3中心-2-电子（3C2E）键（例如B-B-B和B-B-C）的三维的芳族化合物。它们在生物体中未发现，这解释了能够代谢硼簇化合物的酶促体系及其高生物稳定性。此外，硼簇化合物和有机化合物通过不同的机制与生物系统的组分相互作用，例如脂质体系和蛋白质。结果，硼簇化合物的衍生物显示出对抗标准和多毒性抗药性菌株的效力相同。此外，它们显示出抗生物膜活性，并且不太容易引发耐药性。总之，硼簇化合物有可能成为抗菌治疗中的新化学铅，因为它们的衍生物表现出对抗菌活性和对病原体抗性的遗传和表型机制的低敏感性。 （c）2020 Elsevier B.V.保留所有权利。

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  • 来源
    《Coordination chemistry reviews》 |2021年第3期|213684.1-213684.10|共10页
  • 作者

    Fink Krzysztof; Uchman Mariusz;

  • 作者单位

    Charles Univ Prague Fac Sci Dept Phys & Macromol Chem Hlavova 8 Prague 12800 2 Czech Republic|Hirszfeld Inst Immunol & Expt Therapy PAS Lab Biomed Chem R Weigl 12 PL-53114 Wroclaw Poland;

    Charles Univ Prague Fac Sci Dept Phys & Macromol Chem Hlavova 8 Prague 12800 2 Czech Republic;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Boron clusters; Carboranes; Metallacarboranes; Antibiotics; Drug discovery;

    机译：硼簇;碳酸;金属甘蓝烷;抗生素;药物发现;

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