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首页> 外文期刊>Current Colorectal Cancer Reports >Use of Chemotherapy in the Resection of Liver Metastases of Colorectal Cancer
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Use of Chemotherapy in the Resection of Liver Metastases of Colorectal Cancer

机译：化学疗法在结直肠癌肝转移切除中的应用

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R0 resection has proved curative in a subset of patients with colorectal liver metastases. Unfortunately, the incidence of recurrence is high. For this reason, chemotherapy has been used at the preoperative and/or postoperative settings in clearly resectable disease in an attempt to eradicate micrometastasis and, hopefully, increase the oncological benefit of resection. For patients whose disease is not resectable but would become resectable as a result of a substantial response to treatment, chemotherapy is used to “convert” unresectable to resectable disease. This paper will review the use of perioperative chemotherapy, discuss issues regarding administration of chemotherapy before or after surgery, and review evidence regarding the use of specific cytotoxic and targeted agents.
机译：R0切除已被证明可治愈部分结直肠肝转移患者。不幸的是，复发率很高。由于这个原因，在术前和/或术后环境中已将化学疗法用于明显可切除的疾病中，以根除微转移，并希望增加切除的肿瘤学益处。对于那些无法切除但由于对治疗的实质性反应而可能切除的疾病的患者，化疗可用于将无法切除的疾病“转化”为可切除的疾病。本文将回顾围手术期化疗的使用，讨论与手术前后化疗有关的问题，并综述有关使用特定细胞毒性和靶向药物的证据。

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