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首页> 外文期刊>Current Drug Targets >The Central Role Played by Peptides in the Immune Response and the Design of Peptide-Based Vaccines Against Infectious Diseases and Cancer
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The Central Role Played by Peptides in the Immune Response and the Design of Peptide-Based Vaccines Against Infectious Diseases and Cancer

机译：肽在免疫反应中的核心作用以及针对传染病和癌症的基于肽的疫苗的设计

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摘要

Vaccines are one of the most cost effective methods of improving public health thereby increasing the quality of life. Prophylactic and therapeutic treatment by vaccines can prevent infectious diseases and some cancers and could also be used in the treatment of autoimmune disorders. An appreciation of this potential has resulted in a burgeoning literature which not only describes the scientific efforts being made into designing new and improved vaccines but also drives the efforts being made by public health organizations world-wide in delivering vaccines to the community. At the forefront of technologies being applied to the design of vaccines is the use of synthetic peptides the chemical technologies used to assemble peptides have made great strides over the last decade and assembly of hi-fidelity peptides which can be of high molecular weight, multimeric or even branched is now almost routine. Together with the advances in peptide technology our understanding of the molecular events that are neces sary to induce immune responses has also made great strides. The central role that peptides play in immune recognition is now recognised and rules are emerging that are being applied to the construction of peptide-based vaccines that, in the right context, can induce humoral (antibody) and cellular (cytotoxic and helper T cell) immune responses. Synthetic peptides are exquisitely placed to answer questions about immune recognition and along the way to provide us with new and improved vaccines.
机译：疫苗是改善公共卫生从而提高生活质量的最具成本效益的方法之一。疫苗的预防和治疗可以预防传染病和某些癌症，也可以用于治疗自身免疫性疾病。对这种潜力的欣赏导致产生了新兴的文献，这些文献不仅描述了在设计新的和改进的疫苗方面的科学努力，而且推动了全世界公共卫生组织在向社区提供疫苗方面的努力。在疫苗设计技术中最前沿的是合成肽的使用，用于组装肽的化学技术在过去十年中取得了长足的进步，在组装高保真肽方面也取得了长足进步，所述高保真肽可以是高分子量，多聚体或现在即使分支也几乎是常规的。随着肽技术的发展，我们对诱导免疫应答所必需的分子事件的理解也取得了长足的进步。如今，人们已经认识到了肽在免疫识别中所起的核心作用，并且正在制定规则，用于构建基于肽的疫苗，这种疫苗在适当的情况下可以诱导体液（抗体）和细胞（细胞毒性和辅助性T细胞）免疫反应。合成肽的摆放位置可以很好地回答有关免疫识别的问题，并一路为我们提供新的和改良的疫苗。

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