The Biology of Persistent Infection: Inflammation and Demyelination Following Murine Coronavirus Infection of the Central Nervous System

Martin P. Hosking Thomas E. Lane

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The Biology of Persistent Infection: Inflammation and Demyelination Following Murine Coronavirus Infection of the Central Nervous System

机译：持续感染的生物学：鼠冠状病毒感染中枢神经系统后炎症和脱髓鞘。

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Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of humans. Although causes of MS are enigmatic, underlying elements contributing to disease development include both genetic and environmental factors. Recent epidemiological evidence has pointed to viral infection as a trigger to initiating white matter damage in humans. Mouse hepatitis virus (MHV) is a positive strand RNA virus that, following intracranial infection of susceptible mice, induces an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Immune cell infiltration into the central nervous system is critical both to quell viral replication and instigate demyelination. Recent efforts by our laboratory and others have focused upon strategies capable of enhancing remyelination in response to viralinduced demyelination, both by dampening chronic inflammation and by surgical engraftment of remyelination-competent neural precursor cells.

机译：多发性硬化症（MS）是人类的一种免疫介导的脱髓鞘疾病。尽管MS的原因令人费解，但促成疾病发展的潜在因素包括遗传和环境因素。最近的流行病学证据表明，病毒感染是引发人类白质损害的诱因。小鼠肝炎病毒（MHV）是一种正链RNA病毒，在易感小鼠的颅内感染后，会诱发急性脑脊髓炎，该脑炎随后可分解为慢性暴发性脱髓鞘疾病。免疫细胞向中枢神经系统的浸润对于抑制病毒复制和促进脱髓鞘均至关重要。我们实验室和其他研究人员最近的努力集中在能够通过缓解慢性炎症和通过手术植入具有髓鞘作用的神经前体细胞来增强对病毒引起的脱髓鞘反应的髓鞘形成的策略。

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《Current Immunology Reviews》 |2009年第4期|p.267-276|共10页
作者
Martin P. Hosking Thomas E. Lane;
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Department of Molecular Biology&Biochemistry, 3205 McGaugh Hall, University of California, Irvine, CA 92697-3900, USA.;

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1. Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system [J] . Mangale Vrushali, Syage Amber R., Ekiz H. Atakan, Glia . 2020,第11期

机译：微胶质细胞影响宿主防御，疾病和修复后鼠冠状病毒感染中枢神经系统
2. The pathogenesis of murine coronavirus infection of the central nervous system. [J] . Lane TE, Hosking MP Critical reviews in immunology . 2010,第2期

机译：鼠冠状病毒感染中枢神经系统的发病机理。
3. Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection. [J] . Gruslin E, Moisan S, St Pierre Y, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2005,第1a2期

机译：小鼠冠状病毒感染后，小鼠中枢神经系统内的转录组概况和髓磷脂反应性T细胞的活化。
4. Systems Biology and Systems Pharmacology Approaches to HIV Infection and TB/HIV Co-Infection [C] . Elsje Pienaar AIChE Annual Meeting . 2016

机译：系统生物学和系统药理学方法艾滋病毒感染和TB / HIV共感染
5. Receptor utilization and antiviral CD8 T cell responses during central nervous system infection with a murine coronavirus [D] . Bender, Susan J. 2010

机译：受鼠冠状病毒中枢神经系统感染期间的受体利用和抗病毒CD8 T细胞应答
6. The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System [O] . Martin P. Hosking, Thomas E. Lane -1

机译：持续感染生物学：炎症和脱髓鞘后的中枢神经系统的小鼠冠状病毒感染
7. The Biology of Persistent Infection: Inflammation and Demyelination Following Murine Coronavirus Infection of the Central Nervous System [O] . Martin Hosking, Thomas Lane 2009

机译：持续感染的生物学：中枢神经系统鼠冠状病毒感染后炎症和脱髓鞘

The Biology of Persistent Infection: Inflammation and Demyelination Following Murine Coronavirus Infection of the Central Nervous System

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