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首页> 外文期刊>Current Immunology Reviews >Antibodies Against Muscarinic Receptors in Breast Cancer: Agonizing Tumor Growth
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Antibodies Against Muscarinic Receptors in Breast Cancer: Agonizing Tumor Growth

机译：针对乳腺癌中毒蕈碱受体的抗体：使肿瘤生长恶化。

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In developed countries, cancer has replaced infectious diseases as a major cause of death. Currently, efforts innthe immunoprevention of cancer are beginning to resemble that presented by the prevention of infectious diseases by immunizationna century ago. Breast cancer is the most frequent type of tumor in women and is the first cause of death by thisnillness, among them. Moreover, cancer incidence will grow during next years.nSome findings in autoimmunity related to breast cancer in animal models have been important to clarify mechanisms thatnpotentiate tumor growth. Clinical and experimental data now clearly indicate that chronic inflammation significantly contributesnto cancer development. Emerging out of these studies is an appreciation that persistent humoral immune responsesnexacerbate recruitment and activation of innate immune cells in neoplastic microenvironment where they regulate tissuenremodeling, pro-angiogenic and pro-survival pathways that together potentiate cancer development. Generally, antigensninvolved in autoimmune response in breast cancer are modified self-proteins or over-expressed normal proteins that inducenautoantibodies (autoAbs) formation which exhibit tumor promoting actions. This article will review recent resultsnconcerning to the ability of muscarinic acetylcholine receptors (mAChR) expressed in transformed cells, to trigger auto-nAbs formation either in experimental models or in breast cancer patients. We will also discuss the action of these antibodiesnas agonists in mAChR functions.
机译：在发达国家，癌症已取代传染病成为主要的死亡原因。当前，在癌症的免疫预防方面的努力开始类似于二十世纪前通过免疫接种预防传染病所提出的努力。乳腺癌是女性中最常见的肿瘤类型，并且是这种疾病导致的首个死亡原因。此外，癌症的发病率将在未来几年内增加。n在动物模型中与乳腺癌相关的自身免疫性研究的一些发现对于阐明增强肿瘤生长的机制非常重要。现在，临床和实验数据清楚地表明，慢性炎症明显促进了癌症的发展。从这些研究中涌现出来的一种认识是，持续的体液免疫反应会加剧肿瘤微环境中先天免疫细胞的募集和活化，在肿瘤微环境中，它们调节组织重塑，促血管生成和促生存途径，共同促进癌症的发展。通常，在乳腺癌中与自身免疫反应有关的抗原是修饰的自身蛋白或过表达的正常蛋白，其诱导表现出肿瘤促进作用的自身抗体（autoAb）形成。本文将回顾有关转化细胞中毒蕈碱性乙酰胆碱受体（mAChR）表达在实验模型或乳腺癌患者中触发自动nAb形成的能力的最新结果。我们还将讨论这些抗体激动剂在mAChR功能中的作用。

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