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首页> 外文期刊>Current Immunology Reviews >Dendritic Cells: More Than Just Adaptive Immunity Inducers?
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Dendritic Cells: More Than Just Adaptive Immunity Inducers?

机译：树突状细胞：不仅仅是自适应免疫诱导剂？

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摘要

Dendritic cells (DC) are well known for their capacity to induce immune responses and there is also accumulating evidence of their ability to interact with various cell types of the innate system, such as NK, NKT or TCRγδ cells. These interactions are bi-directional, mediated by soluble or cell surface molecules and have been mainly described in the context of immune responses to infectious agents and tumors.nnNK, NKT or TCRγδ cells induce the maturation of DC, as shown by the increased expression of CD86, IL12 production and priming of T cell responses. On the other hand, mature DC have the ability to activate NK, NKT or TCRγδ cells for sustained innate immune responses and activated NK cells may kill immature DC. In addition, DC and NK or TCRγδ cells share similar functions such as cytotoxic and antitumor activity, interferon production and antigen presentation capacity.
机译：树突状细胞（DC）具有诱导免疫反应的能力，众所周知，它们还具有与先天系统的各种细胞类型（例如NK，NKT或TCRγδ细胞）相互作用的能力的证据。这些相互作用是双向的，由可溶性或细胞表面分子介导，主要是在对传染原和肿瘤的免疫反应中进行了描述。 CD86，IL12的产生和T细胞反应的启动。另一方面，成熟的DC具有激活NK，NKT或TCRγδ细胞持续持续的先天免疫应答的能力，而激活的NK细胞可能杀死未成熟的DC。另外，DC和NK或TCRγδ细胞具有相似的功能，例如细胞毒性和抗肿瘤活性，干扰素产生和抗原呈递能力。

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