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Mechanisms of Drosophila Immunity - An Innate Immune System at Work

机译：果蝇免疫的机制-工作中的天然免疫系统。

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Insect immune systems which lack the type of adaptive immunity known in vertebrates rely on several mechanisms including solid barriers against the environment, rapid coagulation of hemolymph after wounding, the formation of aggregates that immobilize and kill foreign invaders, phagocytosis, and the production of antimicrobial peptides. The mode of action and the regulation of the expression of antimicrobial peptides have been studied intensively for more than three decades and are now increasingly well understood. In addition, the characterization of several key molecules involved in other branches of insect immunity has led to a deeper and much more comprehensive understanding of innate immunity in insects. Here we focus on the current status of our view of immunity in the vinegar fly Drosophila melanogaster, the best characterized insect model. We also discuss how evolutionary and ecological forces may have shaped immune responses in Drosophila as compared to other insect species. Finally, several infection models reveal finely-tuned and pathogen-dependent interactions between Drosophila immunity and fly physiology.
机译：缺乏在脊椎动物中已知的适应性免疫类型的昆虫免疫系统依赖于多种机制，包括对环境的坚固屏障，受伤后血淋巴的快速凝结，固定和杀死外来入侵者的聚集体的形成，吞噬作用以及抗菌肽的产生。抗菌肽的作用方式和表达的调节已被深入研究了三十多年，现在已越来越为人所理解。此外，昆虫免疫其他分支中涉及的几个关键分子的表征导致对昆虫固有免疫的更深入，更全面的了解。在这里，我们着眼于我们在醋蝇果蝇（Drosophila melanogaster）中免疫力的最新观点。我们还讨论了与其他昆虫物种相比，果蝇的进化力和生态力如何影响果蝇的免疫反应。最后，几种感染模型揭示了果蝇免疫力与果蝇生理之间的微调和病原体依赖性的相互作用。

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