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首页> 外文期刊>Current Immunology Reviews >The Network of Fibroblastic Reticular Cells in the Lymph Node:Functional Framework for Immune Surveillance
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The Network of Fibroblastic Reticular Cells in the Lymph Node:Functional Framework for Immune Surveillance

机译：淋巴结中的成纤维网状细胞网络：免疫监测的功能框架

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摘要

Lymph nodes (LNs) are crucial organs for triggering adaptive immune responses, and are localized at key places in the network of the lymphatic vascular system in order to filter tissue fluid exudates containing antigens effectively. Within the LN, immune cells are strategically compartmentalized to form a unique tissue architecture that is mechanically and functionally supported by several types of stromal cells of mesenchymal origin. In particular, one of the stromal cell types known as fibroblastic reticular cells (FRCs) produces extracellular matrix fibers and constructs an elaborate network of reticulum that serves as a foothold for immune cells' movement. This network of matrix fibers ensheathed by FRCs also functions as a transport system for low molecular weight materials, including lymph-borne soluble antigens. In addition, FRCs potentially control the localization and homeostasis of immune cells by producing various factors such as adhesion molecules, chemokines, and cytokines. Therefore, this type of less-understood stromal cell component in the LN plays a central role in the spatiotemporal regulation of adaptive immune surveillance.
机译：淋巴结（LNs）是触发适应性免疫反应的关键器官，位于淋巴管系统网络的关键位置，以便有效过滤含有抗原的组织液渗出液。在LN中，策略性地分隔免疫细胞以形成独特的组织结构，该结构由数种间充质来源的基质细胞在机械和功能上进行支持。特别是，一种称为成纤维细胞网状细胞（FRC）的基质细胞可产生细胞外基质纤维，并构建精致的网状网络，从而成为免疫细胞运动的立足点。 FRC包裹的这种基质纤维网络还可以充当低分子量物质（包括淋巴传播的可溶性抗原）的转运系统。此外，FRC可能通过产生各种因素（例如粘附分子，趋化因子和细胞因子）来控制免疫细胞的定位和体内平衡。因此，LN中这种类型的较少了解的基质细胞成分在自适应免疫监视的时空调节中起着核心作用。

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