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首页> 外文期刊>Current Immunology Reviews >Regulation of Innate and Adaptive Immune Responses by a Novel Pattern Recognition Molecule Mindin
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Regulation of Innate and Adaptive Immune Responses by a Novel Pattern Recognition Molecule Mindin

机译：新型模式识别分子Mindin对先天性和适应性免疫反应的调节。

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Extracellular matrix proteins play important roles in many different biological processes. Our recent work has discovered important roles for the ECM protein mindin in both innate and adaptive immune responses. Mindin is a member of the F-spondin family of extracellular matrix proteins, which are classified by the presence of an FS1/FS2 domain and one or more thrombospondin type 1 (TSR) repeats. Mindin is highly conserved throughout evolution and is broadly expressed in several organs including central and peripheral lymphoid tissues. As a component of the extracellular matrix, mindin exerts several important functions in immune responses. Mindin functions as a pattern recognition molecule for microbial pathogen recognition and is required for effective macrophage activation as well as phagocytosis of microbes. In addition, it promotes leukocyte trafficking during inflammation in vivo. Mindin is also essential for the adaptive immune response by inducing small GTPase expression in dendritic cells which is required for efficient T cell priming. These effects are largely mediated through the interaction of mindin with multiple cell surface integrins, which likely results in integrin clustering and the induction of downstream signaling cascades. The focus of this review is to highlight these recent discoveries that demonstrate the necessary roles for mindin during innate and adaptive immunity.
机译：细胞外基质蛋白在许多不同的生物学过程中起重要作用。我们最近的工作发现了ECM蛋白介素在先天和适应性免疫应答中的重要作用。 Mindin是细胞外基质蛋白F-spondin家族的成员，该蛋白通过存在FS1 / FS2域和一个或多个1型血小板反应蛋白（TSR）重复序列进行分类。 Mindin在整个进化过程中都是高度保守的，并在包括中央和外周淋巴组织在内的多个器官中广泛表达。作为细胞外基质的一种成分，思维素在免疫反应中起着重要的作用。 Mindin用作微生物病原体识别的模式识别分子，是有效的巨噬细胞激活以及微生物吞噬功能所必需的。另外，它在体内炎症过程中促进白细胞运输。 Mindin通过在树突状细胞中诱导小GTPase表达，对于适应性免疫反应也是必不可少的，这是有效T细胞启动所必需的。这些作用在很大程度上是通过思维素与多种细胞表面整合素的相互作用来介导的，这很可能导致整合素簇集和下游信号传导级联的诱导。这篇综述的重点是着重介绍这些最近的发现，这些发现证明了先天性和适应性免疫过程中minin的必要作用。

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