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Physiological and Non-Redundant Functions of PKC Isotypes in T Lymphocytes

机译：T淋巴细胞中PKC同种型的生理和非冗余功能

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This review is about the physiological and non-redundant functions of the PKC gene products in hematopoietic cells, particularly T cells. In spite of the large amount of information on PKC functions in various cell types and tissues, the characterization of the isotype selective functions of the entire PKC family in lymphoid cell lineages is far from complete. Given the established important role of PKCθ as regulator of T cell fate and knowing that several other PKC isotypes are also expressed in T cells at a high level, we here summarize the physiological and non-redundant functions of PKCα, β, δ, ε,ζ and θ isotypes in T cells (with emphasis on the ongoing mouse genetic studies). Their known and/or suspected cellular regulation, effector pathways as well as physiological functions are discussed. While PKCβ,ε, δ and appear to be dispensable during cellular activation of primary CD3+ T cells, PKCα and PKCθ take critical parts in signaling pathways that are necessary for full antigen receptor mediated T cell activation and T lymphocyte immunity.
机译：这项审查是有关造血细胞，特别是T细胞中PKC基因产物的生理和非冗余功能。尽管有关各种细胞类型和组织中PKC功能的大量信息，但在淋巴样细胞谱系中整个PKC家族的同种型选择性功能的表征还远远不够。鉴于PKCθ作为T细胞命运的调节者已确立的重要作用，并且知道T细胞中也有其他几种PKC同种型也在高水平表达，我们在此总结PKCα，β，δ，ε， T细胞中的ζ和θ同型（重点在于正在进行的小鼠遗传研究）。讨论了它们的已知和/或疑似细胞调节，效应子途径以及生理功能。虽然在原代CD3 + T细胞的细胞活化过程中PKCβ，ε，δ似乎是可有可无的，但PKCα和PKCθ在信号通路中起着至关重要的作用，这是完全抗原受体介导的T细胞活化和T淋巴细胞免疫所必需的。

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