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首页> 外文期刊>Current Immunology Reviews >The Double Identity of WSX-1 (IL-27R) as an Initiator and an Attenuator of Immune Responses
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The Double Identity of WSX-1 (IL-27R) as an Initiator and an Attenuator of Immune Responses

机译：WSX-1（IL-27R）作为免疫应答的发起者和衰减者的双重身份

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Two heterodimeric cytokines, IL-23 and IL-27, were recently identified, which have structural and functional homology to IL-12. IL-27, composed of p28 plus Epstein Barr Virus-induced gene (EBI)-3, is a member of the IL-12 cytokine family. IL-27 is produced early after activation of antigen-presenting cells and induces proliferation of naïve CD4+ T cells upon antigen recognition. Stimulation of naïve CD4+ T cells with IL-27 through WSX-1, a subunit of functional IL-27 receptor complex, initiates the differentiation of CD4+ T cells into Th1 populations through induction of T-bet followed by expression of IL-12Rb2. IL-27 / WSX-1 thus is critical for proper induction of Th1 responses and lack of WSX-1 results in the impaired Th1 responses in mice. Recent studies revealed that L-27 / WSX-1 signaling also has an anti-inflammatory property. In some protozoan infection, various pro-inflammatory cytokines including TNF-α and IL-6, and even IFN-γ, were over produced, causing lethal inflammatory responses in WSX-1- / - mice. These data revealed that IL-27 / WSX-1 has a suppressive role for pro-inflammatory cytokine production and that IL-27 / WSX-1 may work to suppress and / or terminate immune responses and inflammation. Taken together, IL-27 / WSX-1 thus has double identity as an initiator and as an attenuator of immune responses and inflammation.
机译：最近鉴定了两种异二聚体细胞因子IL-23和IL-27，它们与IL-12具有结构和功能同源性。由p28加上爱泼斯坦巴尔病毒诱导的基因（EBI）-3组成的IL-27是IL-12细胞因子家族的成员。 IL-27在抗原呈递细胞激活后早期产生，并在抗原识别后诱导幼稚CD4 + T细胞增殖。通过功能性IL-27受体复合物的亚基WSX-1用IL-27刺激幼稚的CD4 + T细胞，通过诱导T-bet随后表达IL-12Rb2，将CD4 + T细胞分化为Th1群体。因此，IL-27 / WSX-1对于正确诱导Th1反应至关重要，而缺乏WSX-1会导致小鼠Th1反应受损。最近的研究表明，L-27 / WSX-1信号传导也具有抗炎特性。在某些原生动物感染中，包括TNF-α和IL-6，甚至IFN-γ在内的各种促炎细胞因子被过度生产，从而在WSX-1-/-小鼠中引起致命的炎症反应。这些数据表明，IL-27 / WSX-1对促炎细胞因子的产生具有抑制作用，而IL-27 / WSX-1可能起到抑制和/或终止免疫反应和炎症的作用。总之，IL-27 / WSX-1具有双重身份，既可以作为引发剂，又可以作为免疫反应和炎症的衰减剂。

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