New Aspects of the Role of LFA-1 in Bacterial Infection

Masashi Emoto

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New Aspects of the Role of LFA-1 in Bacterial Infection

机译：LFA-1在细菌感染中作用的新方面

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Leukocyte function-associated antigen (LFA)-1 (CD11a/CD18) is considered to play a pivotal role in a broad range of cellular events, ranging from firm adhesion of leukocytes to endothelial cells initiating leukocyte transmigration and extravasation to functional activation of various inflammatory cells promoting type 1-immune responses. Yet, recent studies argue against the role of LFA-1 in these inflammatory responses. Additionally, recent advances establish LFA-1 as a crucial molecule in regulation of pro-inflammatory and anti-inflammatory cytokine network and in control of granulopoiesis. Thus, it seems likely that LFA-1 plays more complicated/unique roles than originally thought.

机译：白细胞功能相关抗原（LFA）-1（CD11a / CD18）被认为在广泛的细胞事件中起着关键作用，从白细胞的牢固粘附到启动白细胞迁移和外渗的内皮细胞到各种炎症性功能激活细胞促进1型免疫反应。然而，最近的研究反对LFA-1在这些炎症反应中的作用。另外，最近的进展确立了LFA-1作为调节促炎和抗炎细胞因子网络以及控制粒细胞生成的关键分子。因此，LFA-1似乎起着比最初想像的更为复杂/独特的作用。

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来源
《Current Immunology Reviews》 |2005年第2期|p.91-100|共10页
作者
Masashi Emoto;
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作者单位

Laboratory of Immunology, Department of Laboratory Sciences, Gunma University School of HealthSciences, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.;

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正文语种 eng
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关键词
lfa, granulocytes, neutrophilia, il, listeria monocytogenes, lps;

机译：lfa;粒细胞;中性粒细胞;il;李斯特菌;lps;

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New Aspects of the Role of LFA-1 in Bacterial Infection

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