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Mycobacterium tuberculosis and Dendritic Cells: Who's Manipulating Whom?

机译：结核分枝杆菌和树突状细胞：谁在操纵谁？

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摘要

Tuberculosis (TB) remains one of the most common potentially fatal infectious diseases worldwide. The need for more effective vaccines will benefit from a better understanding of the complex interactions between Mycobacterium tuberculosis and the human immune system. Among antigen-presenting cells, dendritic cells (DCs) are thought to play a central role in immunity against this bacillus, and numerous reports published since the early 1990s have focused on this topic. The culmination of the most appealing of these reports suggests the possible ability of M. tuberculosis to manipulate DCs to promote its own survival. These views, however, are rather difficult to reconcile with previous studies demonstrating the ability of mycobacteria-infected DCs to stimulate T lymphocytes in vitro and in vivo, and to confer significant protection against TB, as illustrated in murine models. The immune response elicited in the majority ( > 90%) of infected individuals, though not entirely perfect, is effective enough to allow the peaceful co-existence of the host and the microbe. A more vigorous response might prove sterilizing, but might also prove detrimental to the host tissues by inducing immunopathological injuries. Limiting DC functions to a certain extent may therefore be advantageous for the human host population as a whole, regardless of the 5-10% of infected individuals who will still develop the disease. The underlying question seems to be then: who's manipulating whom?
机译：结核病（TB）仍然是全球最常见的潜在致命传染病之一。对更有效的疫苗的需求将受益于对结核分枝杆菌与人类免疫系统之间复杂相互作用的更好理解。在抗原呈递细胞中，树突状细胞（DC）被认为在抵抗这种芽孢杆菌的免疫中起着核心作用，自1990年代初以来发表的许多报告都集中在这一主题上。这些报告中最引人注目的高潮表明结核分枝杆菌有可能操纵DC来促进其自身生存。但是，这些观点很难与先前的研究相吻合，因为先前的研究证明了分枝杆菌感染的DC在体外和体内刺激T淋巴细胞并赋予针对TB的显着保护的能力，如鼠模型所示。在大多数（> 90％）受感染的个体中引发的免疫反应，尽管并非完全完美，但足以使宿主与微生物和平共处。更强烈的反应可能证明具有杀菌作用，但也可能通过诱导免疫病理性损伤而证明对宿主组织有害。因此，将DC功能限制到一定程度可能对整个人类宿主群都是有利的，而不管仍有5-10％的感染者仍会发展成该疾病。潜在的问题似乎是：谁在操纵谁？

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