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首页> 外文期刊>Current Immunology Reviews >New Insights on the Allergy-Linked β Subunit of the High Affinity IgE Receptor: Mechanisms and Clinical Implications
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New Insights on the Allergy-Linked β Subunit of the High Affinity IgE Receptor: Mechanisms and Clinical Implications

机译：高亲和力IgE受体的过敏相关β亚基的新见解：机制和临床意义。

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摘要

The high affinity IgE Fc receptor (FcεRI) on mast cells and basophils has a central role in allergy and asthma. The β subunit of this multimeric receptor is a membrane tetra-spanning protein that encodes a nonconventional immunoreceptor tyrosine-based activation motif (ITAM) that imparts it signaling competence. This subunit was shown to amplify FcεRI signaling causing increased cellular responses such as degranulation. Polymorphisms of the β subunit have been linked to atopy, asthma, and allergy. Although considerable effort has been made to understand the functional consequence(s) of expressing these polymorphisms, the outcome has not been revealing. Recent studies show a link between β subunit polymorphisms, β gene transcription, and increased FcεRI expression. Additionally, a newly described function for the β subunit suggests an important role in downregulating cytokine production. Among the molecules whose response is dampened by FcεRIb is NFkB, a central regulator of inflammation. Collectively, these studies suggest that the β subunit is important in controlling the sensitivity and extent of an elicited response upon mast cell or basophil activation. Thus the findings, described herein, provide new insights on the mechanistic link between the FcεRIb and allergic disease.
机译：肥大细胞和嗜碱性粒细胞上的高亲和力IgE Fc受体（FcεRI）在过敏和哮喘中起重要作用。该多聚体受体的β亚基是跨膜的跨膜蛋白，其编码非常规免疫受体基于酪氨酸的激活基序（ITAM），从而赋予其信号传导能力。已显示该亚基可放大FcεRI信号传导，从而引起细胞反应增加，例如脱粒。 β亚基的多态性与特应性，哮喘和过敏有关。尽管已经做出了很大努力来理解表达这些多态性的功能结果，但是结果尚未显示出来。最近的研究表明，β亚基多态性，β基因转录和FcεRI表达增加之间存在联系。另外，新描述的β亚基功能表明在下调细胞因子产生中的重要作用。在其响应被FcεRIb抑制的分子中，NFkB是炎症的中央调节剂。总体而言，这些研究表明，β亚基在控制肥大细胞或嗜碱性粒细胞活化后引起的反应的敏感性和程度方面很重要。因此，本文描述的发现提供了关于FcεRIb与变应性疾病之间的机制联系的新见解。

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