The many ways of Wnt in cancer

Paul Polakis

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The many ways of Wnt in cancer

机译：Wnt在癌症中的多种治疗方法

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More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of experiments originating with random proviral integration in mice. The significance of Wnt signaling in human cancer has since been buttressed by the identification of mutations in genes coding for the Wnt pathway components Axin, APC, and β-catenin. This review summarizes the reported genetic defects in the Wnt pathway, with an emphasis on their functional contribution to human tumor progression.

机译：20多年前，Wnt配体的致癌性在一系列源自小鼠随机前病毒整合的实验中得以揭示。此后，通过鉴定编码Wnt途径组分Axin，APC和β-catenin的基因中的突变，支持了Wnt信号在人类癌症中的重要性。这篇综述总结了Wnt途径中已报道的遗传缺陷，并着重指出了其对人类肿瘤进展的功能性贡献。

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《Current Opinion in Genetics & Development》 |2007年第1期|p.45-51|共7页
作者
Paul Polakis;
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Department of Research, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA;

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正文语种 eng
中图分类遗传学;
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1. Autocrine Activation of the Wnt/???2-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers Autocrine Activation of the Wnt/???2-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers Autocrine Activation of the Wnt/???2-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers [J] . Peiman Shooshtarizadeh, Alain Nepveu, Charles Vadnais, Biology Open . 2014,第10期

机译：Cux1和GLIS1在乳腺癌中Wnt / ??? 2-Catenin途径的自分泌激活在乳腺癌中WUX /？2-Catenin途径在Cux1和GLIS1中的自分泌激活Wnt / ??? 2的自分泌激活CUX1和GLIS1在乳腺癌中的-Catenin途径
2. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
3. A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers [J] . Kamal Ahmed, Holly V. Shaw, Alexey Koval, Cancers . 2016,第7期

机译：旧药的第二种WNT：针对WNT依赖性癌症的药物重新定位
4. Genetic profiling of breast cancer: A case study on Wnt and BRCA pathways [C] . Dwi Listyorini, Justinus Dwi Pratjojo Wisnubroto, Alfiyannul Akhsan, International Conference on Biological Science . 2020

机译：乳腺癌的遗传分析：WNT和BRCA通路的案例研究
5. Cutting of single-walled carbon nanotubes (SWNT): (1) Cutting of pristine SWNT by ozonolysis; (2) Ozonolysis of functionalized SWNT; (3) Cutting ozonated SWNT by e-irradiation; (4) Cutting fluorinated SWNT by pyrolysis. [D] . Chen, Zheyi. 2006

机译：切割单壁碳纳米管（SWNT）：（1）通过臭氧分解切割原始SWNT；（2）功能化单壁碳纳米管的臭氧分解；（3）通过电子辐照切割臭氧化的SWNT；（4）通过热解切割氟化SWNT。
6. Up-regulation of Wnt7b rather than Wnt1 Wnt7a and Wnt9a indicates poor prognosis in breast cancer [O] . Jian Chen, Tian-Yu Liu, Hai-Tao Peng, 2018

机译：Wnt7b而不是Wnt1Wnt7a和Wnt9a的上调指示乳腺癌的预后不良
7. ID3010 Wnt antagonism in cancer stem cells- targeting stemness of cancers via the Wnt-BETA catenin pathway [O] . Sudha Warrier 2017

机译：ID3010 WNT对癌症干细胞的拮抗作用 - 癌症通过Wnt-βcatenin途径靶向茎

The many ways of Wnt in cancer

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