Transcription factors in hematopoietic malignancies

Sigal Gery; H Phillip Koeffler

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Transcription factors in hematopoietic malignancies

机译：造血系统恶性肿瘤的转录因子

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Transcription factors comprise a high proportion of the proteins with dysregulated expression or altered activity in cancer cells. In recent years, great progress has been made in elucidating crucial pathways in leukemogenesis, partially by identifying key transcription factors that are normally indispensable for hematopoiesis but which are often associated with malignant transformation when functioning improperly. The significance of transcription factors is highlighted by the multiple mechanisms used by leukemic cells to abrogate their normal activity. Delineating these mechanisms can benefit the diagnosis and treatment of hematological malignancies and might also be applicable to certain solid tumors.

机译：转录因子包括在癌细胞中表达失调或活性改变的蛋白质的大部分。近年来，在阐明白血病发生中的关键途径方面取得了很大进展，部分是通过鉴定通常对于造血不可缺少的关键转录因子，但在功能异常时通常与恶性转化有关。白血病细胞用于消除其正常活性的多种机制突显了转录因子的重要性。描述这些机制可以有益于血液系统恶性肿瘤的诊断和治疗，也可能适用于某些实体瘤。

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《Current Opinion in Genetics & Development》 |2007年第1期|p.78-83|共6页
作者
Sigal Gery; H Phillip Koeffler;
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作者单位

Cedars-Sinai Medical Center, Division of Hematology-Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA;

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正文语种 eng
中图分类遗传学;
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3. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies? [J] . Hillion J, Dhara S, Sumter TF, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2008,第24期

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Transcription factors in hematopoietic malignancies

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