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Admixture mapping as a tool in gene discovery

机译:混合物映射作为基因发现的工具

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摘要

Admixture mapping is a rapidly developing method to map susceptibility alleles in complex genetic disease associated with continental ancestry. Theoretically, when admixture between continental populations has occurred relatively recently, the chromosomal segments derived from the parental populations can be deduced from the differences in genotype allele frequencies. Progress in computational algorithms, in identification of ancestry informative single nucleotide polymorphisms, and in recent studies applying these tools suggests that this approach will complement other strategies for identifying the variation that underlies many complex diseases.
机译:混合作图是一种快速发展的方法,用于绘制与大陆血统有关的复杂遗传病中的易感性等位基因。从理论上讲,当大陆种群之间的混合发生得相对较近时,可以从基因型等位基因频率的差异中推断出来自亲本种群的染色体片段。计算算法的发展,祖先信息丰富的单核苷酸多态性的鉴定以及最近使用这些工具的研究表明,这种方法将补充其他鉴定许多复杂疾病基础变异的策略。

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  • 来源
    《Current Opinion in Genetics & Development》 |2007年第3期|p.177-181|共5页
  • 作者

    Michael F Seldin;

  • 作者单位

    Rowe Program in Human Genetics, Departments of Biochemistry and Medicine, Room 4453, Tupper Hall Department of Biological Chemistry, One Shields Avenue, University of California, Davis, CA 95616, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遗传学;
  • 关键词

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