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Computational modelling of epithelial patterning

机译:上皮模式的计算模型

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The generation of polar cell polarity (PCP) can be regarded as a pattern-forming process. Pattern formation requires local self-enhancement and long-range inhibition that can take place either within a cell or between adjacent cells. A comparison of this general condition with implementations in molecular terms in recent PCP models facilitates an understanding of inherent similarities and differences between them. In addition, it is important to integrate the most interesting and still valid results of classical transplantation experiments that were made some 40 years ago. They remind us that the global polarizing signal is based on graded positional identities carried by the individual cells whose molecular nature is still unknown.
机译:极性电池极性(PCP)的产生可以被视为图案形成过程。模式形成需要局部自我增强和远距离抑制,这种自我增强和远距离抑制可能发生在一个细胞内或相邻细胞之间。将这种一般条件与最新PCP模型中的分子实现方式进行比较有助于理解它们之间的固有相似性和差异。此外,重要的是整合40年前所做的最有趣且仍有效的经典移植实验结果。他们提醒我们,全局极化信号基于分子性质仍未知的单个细胞携带的分级位置标识。

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