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首页> 外文期刊>Current Opinion in Genetics & Development >We gather together: insulators and genome organization
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We gather together: insulators and genome organization

机译：我们聚在一起：绝缘子和基因组组织

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摘要

When placed between an enhancer and promoter, certain DNA sequence elements inhibit enhancer-stimulated gene expression. The best characterized of these enhancer-blocking insulators, gypsy in Drosophila and the CTCF-binding element in vertebrates and flies, stabilize contacts between distant genomic regulatory sites leading to the formation of loop domains. Current results show that CTCF mediates long-range contacts in the mouse β-globin locus and at the Igf2/H19-imprinted locus. Recently described active chromatin hubs and transcription factories also involve long-range interactions; it is likely that CTCF interferes with their formation when acting as an insulator. The properties of CTCF, and its newly described genomic distribution, suggest that it may play an important role in large-scale nuclear architecture, perhaps mediated by the co-factors with which it interacts in vivo.
机译：当置于增强子和启动子之间时，某些DNA序列元件会抑制增强子刺激的基因表达。这些增强剂阻隔的绝缘子（果蝇中的吉普赛人和脊椎动物和果蝇中的CTCF结合元件）最有特色的是，它们稳定了遥远的基因组调控位点之间的接触，从而导致环域的形成。当前结果表明，CTCF介导了小鼠β珠蛋白基因座和Igf2 / H19印迹基因座的远程接触。最近描述的活性染色质集线器和转录工厂还涉及远程相互作用。当用作绝缘体时，CTCF可能会干扰其形成。 CTCF的性质及其新描述的基因组分布表明，它可能在大规模核结构中发挥重要作用，也许是由它在体内与其相互作用的辅因子介导的。

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