Biocatalysis in the Preparation of the Statin Side Chain

Arto Liljeblad Annukka Kallinen Liisa T. Kanerva

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Biocatalysis in the Preparation of the Statin Side Chain

机译：制备他汀类侧链的生物催化

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Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

机译：用于治疗血脂异常的他汀类药物是世界上最畅销的药物。工业规模上他汀类药物的经济生产具有挑战性，因为他汀类药物的侧链是由两个不对称中心组成的3,5-二羟基酸衍生物。制备侧链最突出的方法是基于生物催化并在本综述中进行了调查。

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《Current Organic Synthesis》 |2009年第4期|p.362-379|共18页
作者
Arto Liljeblad Annukka Kallinen Liisa T. Kanerva;
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作者单位

Pharmacology, Drug Development and Therapeutics, Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkaisenkatu 5 C, FIN-20520, Turku, Finland.;

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正文语种 eng
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关键词
Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase;

机译：他汀;心血管疾病;生物催化;脱氢酶;脂肪酶;卤代醇脱卤酶;腈水解酶;醛缩酶;

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专利

1. Biocatalysis in the Preparation of the Statin Side Chain [J] . Liljeblad A, Kallinen A, Kanerva LT Current Organic Synthesis . 2009,第4期

机译：制备他汀类侧链的生物催化
2. Nitrilase-catalysed desymmetrisation of 3-hydroxyglutaronitrile: Preparation of a statin side-chain intermediate [J] . Bergeron S, Chaplin DA, Edwards JH, Organic process research & development . 2006,第3期

机译：硝化酶催化的3-羟基戊二腈去对称化反应：他汀类侧链中间体的制备
3. Biocatalysis for the Production of Pharmaceutical Intermediates: Statin Precursors [J] . A. ?varc, D. Skendrovi?, A. Vrsalovi? Prese?ki Kemija u industriji . 2019,第9a10期

机译：生物催化生产医药中间体：他汀前体
4. Preparations, Molecular Assemblies, and Physical Properties of Benzenecarboxamides Bearing Hydrophobic CONHC10H21 Chains and Hydrophilic ?CONH(CH CH O) CH Chains [C] . Xiaozhu Jing, Takashi Takeda, Norihisa Hoshino 日本化学会春季年会講演予稿集 . 2018

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5. Preparation and the Characterization of a Ferrocene Containing Main-Chain PEG-CNT Phase for Hybrid Supercapacitor Application [D] . Rahangdale, Shalaka. 2018

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6. Nanoarmoring: strategies for preparation of multi-catalytic enzyme polymer conjugates and enhancement of high temperature biocatalysis [O] . Omkar V. Zore, Paritosh Pande, Oghenenyerovwo Okifo, -1

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7. Biocatalysis in the Preparation of the Statin Side Chain [O] . Arto Liljeblad, Annukka Kallinen, Liisa T. Kanerva 2013

机译：制备他汀类侧链的生物催化

Biocatalysis in the Preparation of the Statin Side Chain

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