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首页> 外文期刊>Cytology and genetics >Protein Kinase KIN10 from Arabidopsis thaliana as a Potential Regulator of Primary Microtubule Nucleation Centers in Plants
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Protein Kinase KIN10 from Arabidopsis thaliana as a Potential Regulator of Primary Microtubule Nucleation Centers in Plants

机译：拟南芥中的蛋白激酶KIN10作为植物初级微管成核中心的潜在调节剂

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摘要

The nearest plant homologues of animal protein kinase BRSK were identified using the methods of classical and structural bioinformatics. The selection was performed based on the sequence comparison, results of phylogenetic clustering, and analysis of domain architecture. Spatial structures of human BRSK1 and KIN10 from A. thaliana were compared. The relationship between KIN10 and the regulation of primary microtubule nucleation centers in A. thaliana was revealed. Obvious homology of plant KIN10 and mammalian BRSK1 evidence to suggest that this plant protein kinase is associated with the regulation of the structure and function of primary microtubule nucleation centers and is able to phosphorylate gamma-tubulin from Arabidopsis (TUBG1 and TUBG2) at Ser131, affecting the gamma TuSC monomer structure as well as the gamma TuRC complex assembly. The effect of the modification on the TUBG1-GACP3 interaction was suggested.
机译：使用经典和结构生物信息学方法鉴定了动物蛋白激酶BRSK的最近植物同源物。选择是基于序列比较，系统发生聚类的结果以及域结构分析进行的。比较了拟南芥人BRSK1和KIN10的空间结构。揭示了KIN10与拟南芥初级微管成核中心调控之间的关系。植物KIN10和哺乳动物BRSK1的明显同源性表明该植物蛋白激酶与初级微管成核中心的结构和功能的调节有关，并且能够使Ser131的拟南芥（TUBG1和TUBG2）的γ-微管蛋白磷酸化，从而影响γTuSC单体结构以及γTuRC配合物组装体。建议了该修饰对TUBG1-GACP3相互作用的影响。

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